成都地区非酒精性脂肪肝患病率及危险因素分析

目的]探讨健康体检人群中非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)的患病率以及其危险因素,为非酒精性脂肪性肝病防治提供依据。方法]以参与健康体检的3079例人群为研究对象,收集相关体检资料进行统计学分析。结果]非酒精性脂肪性肝病总检出率为12.18%,男性患病率明显高于女性,且有明显的年龄差异(P﹤0.001);NAFLD组体重指数、血压、空腹血糖、肝功、血脂和低密度脂蛋白水平均高于对照组,高密度脂蛋白低于对照组;除冠心病外,NAFLD组吸烟、肥胖、高血压、高血糖、高脂血症和胆结石的患病率均高于对照组;多因素非条件Logistic回归分析示高血压、高低密度脂蛋白、高甘油三酯、血糖异常、男性和肥胖是NAFLD的独立危险因子,且其相对危险度依次升高,以血糖异常、男性和肥胖最高。结论]NAFLD的发生与肥胖、男性和高脂血症密切相关,且非酒精性脂肪性肝病患者的高血压、高血糖、胆结石的患病率也高于健康人,须重视防治非酒精性脂肪性肝病。

ANALYSIS OF THE PREVALENCE OF NONALCOHOLIC FATTY LIVER DISEASE AND ITS RISK FACTORS

Objective] To investigate the prevalence of nonalcoholic fatty liver disease and its risk factors among the people took health checkup and provide scientific bases for prevention and treatment. Methods] The medical examination results of 3 079 cases were collected for statistical analysis. Results] The total incidence of nonalcoholic fatty liver disease in our study was 12.18%. The rate was higher in male than in female and had significant difference with age. The means of BMI, blood pressure, fasting blood glucose (FBG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood fat and low density lipoprotein-cholesterol (LDL-C) were higher in NAFLDs while high-density lipoprotein cholesterol (HDL-C) was lower. The prevalence of smoking, obesity, hypertension, hyperlipemia, hyperglycaemia and gallstone in NAFLDs was higher than that of control group. Multiple logistic regression analysis revealed that risk factors of NAFLD included obesity, male, hyperglycaemia, hyperlipemia, high HDL-C and hypertension. Conclusion] NAFLD is closely associated with obesi- ty, male and hyperlipemia. The prevalence of obesity, hypertension, hyperglycaemia, gallstone in NAFLDs is high. It is important to prevent and treat nonalcoholic fatty liver disease.