银杏叶提取物治疗慢性肺源性心脏病40例临床观察

目的观察银杏叶提取物辅助治疗慢性肺源性心脏病（简称肺心病）急性加重期的疗效及治疗前后血浆C反应蛋白、纤维蛋白原、D-二聚体含量的变化。方法观察40例肺心病急性加重期患者在常规治疗基础上,加用银杏提取物20ml加入5%葡萄糖注射液（或生理盐水）中静脉滴注,1次/d,14d为1个疗程。另38例以常规治疗为对照组。结果两组显效率分别为87.50%和68.42%,总有效率为97.50%和86.84%,差异有统计学意义（P〈0.05）;治疗后两组间血浆C反应蛋白含量差异有统计学意义（P〈0.01）,纤维蛋白原、D-二聚体含量差异有有统计学意义（P〈0.05）。结论银杏叶提取物可明显改善机体炎症反应,降低血黏度,提高肺心病急性加重期的临床疗效。

Clinical observation of the ginkgo biloba extract on the treatment of 40 cases with chronic pulmonary heart disease

Objective To observe the curative effect of ginkgo biloba extract on the treatment of chronic pulmonary heart disease at the acute exacerbation stage,and the changes of plasma C reactive protein,fibrinogen and D-dimer between pre and post treatment.Methods The ginkgo biloba extract 20 ml/d were given by intravenous drip for 14 days as a course of treatment based on the routine treatment in 40 cases with chronic pulmonary heart disease at acute exacerbation stage,which were dissolved into 5%glucose injection or 0.9%sodium chloride injection..The other 38 cases with routine treatment served as control group.Results The obvious effective rate and total effective rate of the treatment group were 87.50%and 97.50%.The control group were 68.42%and 86.84%.There were significant differences between the 2 groups(P<0.01).To compare the level of plasma C reactive protein after treatment between 2 groups,the difference was highly significant(P<0.01).To compare the level of the plasma fibrinogen and D-dimer after treatment,there were significant differences between the 2 groups(P<0.05).Conclusion The ginkgo biloba extract could obviously decrease systemic inflammatory response,reduce blood viscosity and improve the clinical efficacy on chronic pulmonary heart disease at the acute exacerbation stage.