| 安徽省一线抗反转录病毒治疗失败的AIDS病人的耐药基因变异分析 |
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| 引用本文： | 沈月兰,苏斌,吴建军,刘爱文,程晓莉. 安徽省一线抗反转录病毒治疗失败的AIDS病人的耐药基因变异分析[J]. 中国艾滋病性病, 2011, 0(3): 295-297,301 |
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| 作者姓名： | 沈月兰 苏斌 吴建军 刘爱文 程晓莉 |
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| 作者单位： | 安徽省疾病预防控制中心; |
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| 基金项目： | 全球基金中国艾滋病项目(CHN-304-G03-H) |
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| 摘 要： | 目的了解安徽省一线抗反转录病毒治疗失败的艾滋病(AIDS)病人耐药基因变异情况。方法调查一线抗反转录病毒治疗失败的AIDS病人的人口学及流行病学特征,检测CD4及病毒载量,对病毒载量高于1 000拷贝/ml的病人进行基因型耐药检测。结果共调查61例AIDS病人,其中有41例病毒载量高于1 000拷贝/ml。40例成功扩增序列,基因型耐药检测的成功率为97.56%(40/41)。在40例AIDS病人中,核苷类反转录酶抑制剂(NRTI)相关耐药基因突变率居于前三位的,分别是M184V、T215Y和M41L,非核苷类反转录酶抑制剂(NNRTI)相关基因耐药突变率居于前三位的,分别是K103N、Y181C和G190A,没有发现与蛋白酶抑制剂(PI)相关耐药基因突变。结论一线抗反转录病毒治疗失败的主要原因是出现NRTI和NNRTI耐药突变。在选择二线治疗方案时,要充分利用基因耐药检测评估抗反转录病毒药物的敏感性,尽量使用对HIV敏感的抗病毒药物,增加PI类药物,避免交叉耐药带来的治疗失败。
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| 关 键 词： | 艾滋病 耐药变异 一线抗反转录病毒治疗 |
An analysis of patterns of HIV drug resistance in case of failure of first-line anti-retroviral therapy |
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| SHEN Yue-lan,SU Bin,WU Jian-jun,et al.. An analysis of patterns of HIV drug resistance in case of failure of first-line anti-retroviral therapy[J]. Chinese JOurnal of Aids & STD, 2011, 0(3): 295-297,301 |
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| Authors: | SHEN Yue-lan SU Bin WU Jian-jun et al. |
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| Affiliation: | SHEN Yue-lan,SU Bin,WU Jian-jun,et al.(Anhui Provincial Center for Disease Control and Prevention,Hefei,Anhui 230601,China) |
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| Abstract: | Objective To know HIV drug resistance mutations after failure of highly active anti-retroviral therapy.Methods Demographic and epidemiological characteristics in 61 AIDS patients were surveyed.Blood samples were drawn for CD4 count and viral level(VL) test,and HIV drug resistance mutations were analyzed for AIDS patients whose viral level was greater than 1000 cp/ml.Results There were 41 cases whose VL was above 1 000cp/ml,40 cases were successful in PCR,and HIV drug resistance detection rate was 97.56%(40/... |
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| Keywords: | AIDS patient Drug resistance mutations First-line anti-retroviral therapy |
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