| 人参二醇组皂甙对大鼠皮层神经元钙通道的影响 |
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| 引用本文： | 开丽,王中峰.人参二醇组皂甙对大鼠皮层神经元钙通道的影响[J].中国药理学通报,1998,14(1):53-56. |
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| 作者姓名： | 开丽 王中峰 |
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| 作者单位： | 第三军医大学基础部药理教研室 |
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| 摘 要： | 目的研究人参二醇组皂甙（ＰＤＳ）对大鼠大脑皮层神经元膜Ｌ－型钙通道单通道电活动的影响。方法急性分离大鼠皮层神经元和细胞贴附膜片钳技术。结果ＰＤＳ（１．５ｇＬ－１）可明显缩短大鼠皮层神经元Ｌ－型钙通道的平均开放时间，延长其平均关闭时间，降低其开放概率，而对该通道的电流幅值无明显影响，其作用与经典钙通道阻断剂ｖｅｒａ－ｐａｍｉｌ相似但较弱。结论ＰＤＳ对大鼠皮层神经元Ｌ－型通道有明显阻滞作用。
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| 关 键 词： | 膜片钳 离子通道 钙 皮层神经元 人参 皂甙类 大鼠 |
Effect of panaxadiol saponins on calcium channels in cortical neurons of rats |
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| Abstract: | AIM To study the effects of panaxadiol saponins (PDS) on the single channel activity of L type calcium channel in cortical neurons of rats. METHODS Using patch clamp technique of cell attached configuration and acutely isolated cortical neurons of wistar rats. RESULTS PDS (15 g·L-1) shortened the open time of L type calcium channel, prolonged the close time, decreased the open state probability, but exerted no effects on the amplitude of ionic current flow through the Ca2+ channel. The actions of PDS were similar to those of verapamil, a potent calcium channel blocker, but the effects of PDS were less than those of verapamil. CONCLUSION PDS has the blockade effects on the L type calcium channel in cortical neurons of rats. |
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| Keywords: | patch clamp ion channel calcium cortical neurons ginseng saponins rat |
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