垂体腺瘤中MMP-9及TIMP-1表达与肿瘤生物学行为的关系

目的　探讨MMP 9及其抑制因子TIMP 1在垂体腺瘤中表达与肿瘤生物学行为的关系。方法　应用免疫组化S P法检测上述基因蛋白在 2 3例侵袭性和 2 4例非侵袭性垂体腺瘤组织中的表达。结果　侵袭性垂体腺瘤组中MMP 9的表达和MMP 9表达超过TIMP 1的比例高于非侵袭性腺瘤组 (P <0 0 5 ) ;TIMP 1在侵袭性垂体腺瘤组的表达有降低的趋势 ,但无统计学意义 (P >0 0 5 ) ;MMP 9与TIMP 1表达呈正相关 (P <0 0 5 )。结论　MMP 9表达上调导致其和TIMP 1的表达失衡与垂体腺瘤侵袭性有关 ,MMP 9可作为评估垂体腺瘤侵袭性的分子生物学指标

Correlation of expression of MMP-9 and TIMP-1 with biological behaviors in pituitary adenomas

Purpose To study the correlation of expression of MMP-9 and TIMP-1 with biological behaviors in pituitary adenomas. Methods The expression of MMP-9 and TIMP-1 was determined by immunohistochemical S-P method in 23 case of invasive adenomas and 24 non-invasive adenomas. Results The invasive group had a significantly higher expression of MMP-9 and proportion of MMP-9/TIMP-1 expression more than that of non-invasive group (P<0.05). A significant difference was not found for expression of TIMP-1 between two groups(P>0.05), but there was a positive relation between expression of MMP-9 and TIMP-1(P<0.05). Conclusions Imbalance of expression between MMP-9 and TIMP-1 deriving from overexpression of MMP-9 is positively related to invasiveness of pituitary adenomas. MMP-9 can be taken as a molecular biological indicator to evaluate its invasive potential.