反流性食管炎与幽门螺杆菌的相关性研究

目的 研究反流性食管炎(RE)与幽门螺杆菌(H.pylori)感染的相关性。方法 检测RE、正常对照、慢性胃炎和十二指肠溃疡组及各级RE患者的H.pylori感染率。选取40例内镜分级B或C级的RE患者,H.pylori阳性及阴性各20例,雷贝拉唑治疗4周后内镜复查,比较治疗效果。结果 RE组、正常组、慢性胃炎组、十二指肠溃疡组的H.pylori感染率分别为30.4%、28.8%、59.0%、91.5%,RE组感染率显著低于胃炎组和溃疡组,与正常人群无明显差异;各级RE患者的H.pylori感染率无明显差异;RE患者经雷贝拉唑治疗后,H.pylori阳性组与阴性组的病变愈合和症状改善情况无明显差异。结论 RE与H.pylori感染可能无相关性。

Association of reflux esophagitis with Helicobacter pylori

Objective To investigate the association of the pathogenesis of reflux esophagitism (RE) with Helicobacter pylori (H. pylori) infection. Methods The prevalences of H. pylori among the patients with RE, normal control subjects, patients with chronic gastritis and patients with duodenal ulcer, as well as the prevalence of H. pylori infection in RE patients of each grade, were compared. Forty patients with endoscopically verified RE grades B or C, along with 20 patients with and another 20 without H. pylori infection were enrolled to receive a 4-week course of rabeprazole treatment, and the subsequent healing rates and symptom relief were compared. Results The prevalences of H. pylori in groups RE, control, chronic gastritis and duodenal ulcer were 30.4%, 28.8%, 59.0% and 91.5% respectively. The rate of H. pylori infection in patients with RE was significantly lower than that in those with chronic gastritis and duodenal ulcer, but was comparable with that in the control subjects. H. pylori infection varied little among RE patients of different grades. In RE patients positive or negative for H. pylori, the healing rates and relief of the symptoms were not different after the treatment. Conclusion H. pylori infection might not be responsible for the susceptibility to RE.