幽门螺杆菌与反流性食管炎关系探讨

目的通过对10年来H．pylori感染和RE病例的调查，分析H．pylori感染与反流性食管炎的关系。方法回顾分析比较该院1995年1月-2004年12月问诊断的H．pylori感染和食管炎检出率及H．pylori阴性与阳性RE分级的比例关系。结果RE组H．pylori阳性率低于受检人群（24．72％vs42．30％，P=0．00），H．pylori阳性R正检出率低于阴性（2．13％vs 4．75％，P=0．00）。10年间受检人群和R正人群H．pylori阳性率下降，RE检出率上升。轻度RE（A和B级）H．pylori阳性率为24．65％，中一重度RE（C和D级）H．pylori阳性率为25．10％，二者间H．pylori阳性率差异无统计学意义（P=0．88）。结论虽然RE人群H．pylori感染低于一般人群，H．pylor感染与反流性食管炎程度无关。

Discussion of relation between Helicobacter pylori infection and reflux esophagitis

[Objective] To investigate prevalence of H.pylori infection among the patients underwent endoscopic examination and patients with reflux esophagitis and to evaluate relation between H.pylori infection and reflux esophagitis.[Methods] In this retrospective study,we aimed to examine the prevalnce of H.pylori infection and reflux esophagitis and proportion of the grades in reflux esophagitis in our hospital from January 1995 to December 2004.[Results] H.pylori infection was less prevalent among the patients with RE(24.72%),compared with non-RE subjects(42.30%).The prevalenec of RE in H.pylori-positive patients was lower than H.pylori-negative patients(2.13% vs 4.75%,P =0.00).The prevalence was singnificantly decreasing in the patients with RE and non-RE during the past decade,but prevalence of patient with RE was increased.There was no significant difference in H.pylori infection status between mild grade of RE(grades A and B)and median-severely grade of RE(grades C and D)(24.65%vs25.10%,P =0.876).[Conclusion] Although H.pylori infection was less prevalent among the patients with RE,the severity of RE was not correlated to H.pylori infection status.