硫酸钙人工骨椎弓根植骨修复胸腰段椎体爆裂性骨折

背景：硫酸钙人工骨是一种椎体内植骨材料，具有较好的融合效果，可有效纠正矢状位畸形和序列，维持椎体高度。目的：探讨硫酸钙人工骨椎弓根植骨治疗胸腰段椎体爆裂性骨折的临床疗效。方法：将46例胸腰段椎体爆裂性骨折患者随机分为植骨组（n=21）和非植骨组（n=25），分别进行硫酸钙人工骨椎弓根植骨治疗与单纯椎体成形治疗，比较两组患者术后卧床时间、末次随访目测类比评分、伤椎前缘高度、空壳现象发生率、内固定失效率等差异。结果与结论：46例患者术后均完成12个月随访，植骨组和非植骨组患者平均随访时间分别为18.70个月和17.48个月。非植骨组患者术后卧床时间明显长于植骨组（P=0.002），空壳现象和内固定失效发生率显著高于植骨组（P=0.036，P=0.038）。然而，两组患者末次随访目测类比评分及不同时间伤椎前缘高度百分比比较，差异均无显著性意义（P均〉0.05）。结果表明硫酸钙人工骨椎弓根植骨治疗胸腰段单椎体爆裂性骨折的临床疗效及安全性优于单纯椎体成形治疗。

Calcium sulfate artificial bone for repair of thoracolumbar burst fractures

BACKGROUND： Calcium sulfate artificial bone acts as a kind of bone graft material within the vertebral body, has good fusion effect and can effectively correct sagittal deformity and sequence to maintain the vertebral height. OBJECTIVE： To assess the clinical effects of calcium sulfate artificial bone in the treatment of thoracolumbar burst fractures. METHODS： Forty-six thoracolumbar burst fracture patients were randomly divided into a bone graft group （21 patients undergoing treatment with calcium sulfate artificial bone） and a non-bone graft group （25 patients undergoing vertebroplasty alone）. The efficacy of the two types of surgery was compared in terms of postoperative recovery time, visual analog scale score at the final follow-up, anterior vertebral height, incidence of ghost vertebral phenomenon and failure rate of internal fixation. RESULTS AND CONCLUSION： All patients were followed up for 12 months. Patients in the bone graft group and non-bone graft group were followed up for an average of 18.7 months and 17.48 months, respectively. The postoperative recovery time of patients in the bone graft group was shorter than that in the non-bone graft group （P=-0.002）; the incidence of ghost vertebral phenomenon and internal fixation failure rate in the bone graft group were lower than those in the non-bone graft group （P=-0.036, P=-0.038）. However, there were no significantly statistical differences between two groups in visual analog scale score at the final follow-up and anterior vertebral height at different time （all P 〉 0.05）. These findings indicate that calcium sulfate artificial bone for thoracolumbar burst fractures is effective and safe, which is superior to vertebropiasty alone.