In vitro controlled release of clove essential oil in self-assembly of amphiphilic polyethylene glycol-block-polycaprolactone |
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| Authors: | O. Thonggoom N. Punrattanasin N. Srisawang N. Promawan R. Thonggoom |
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| Affiliation: | 1. Department of Textile Science and Technology, Faculty of Science and Technology, Thammasat University, Pathumthani, Thailand;2. tornsiri@tu.ac.th;5. ornsirithonggoom@gmail.com;6. Materials Science and Engineering Program, Faculty of Science, Mahidol University, Bangkok, Thailand;7. Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand;8. Center for Surface Science and Engineering, Faculty of Science, Mahidol University, Nakhon Pathom, Thailand |
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| Abstract: | In this study, a micellar delivery system with an amphiphilic diblock copolymer of poly (ethylene glycol) and poly (?-caprolactone) was synthesised and used to incorporate hydrophobic clove essential oil (CEO). To determine an optimal delivery system, the effects of the copolymer’s hydrophobic block length and the CEO-loading content on the encapsulation of CEO were investigated. Percentages of entrapment efficiency (%EE), CEO loading (%CEO), and in vitro release profiles were determined. The size, size distribution, zeta potential, and morphology of the obtained micelles were determined by DLS, FE-SEM, and TEM. The %EE, %CEO, and in vitro release profiles of CEO incorporated in micelles were analysed by HPLC. The study revealed a sustained release profile of CEO from CEO-loaded micelles. The results indicate the successful formulation of CEO-loaded PEG-b-PCL micelle nanoparticles. It is suggested that this micelle system has considerably potential applications in the sustained release of CEO in intravascular drug delivery. |
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| Keywords: | clove essential oil amphiphilic micelle PEG PCL controlled release biodegradable polymer |
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