| 阿奇霉素对华法林抗凝效果的影响 |
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| 引用本文： | 吴薇,李艳,鲁志兵. 阿奇霉素对华法林抗凝效果的影响[J]. 国际检验医学杂志, 2013, 34(23): 3125-3126 |
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| 作者姓名： | 吴薇 李艳 鲁志兵 |
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| 作者单位： | 吴薇 (武汉大学人民医院检验科,湖北武汉,430060武汉大学人民医院临床分子诊断中心,湖北武汉,430060)； 李艳 (武汉大学人民医院检验科,湖北武汉,430060武汉大学人民医院临床分子诊断中心,湖北武汉,430060)； 鲁志兵 (武汉大学人民医院心内科,湖北武汉,430060)； |
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| 基金项目： | 国家自然科学基金资助项目(项目编号：81200389),教育部高等学校博士学科点专项科研基金资助项目(项目编号：20120141120077)教育部中央高校基本科研业务专项基金资助项目(项目编号：121069) |
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| 摘 要： | 目的探讨阿奇霉素对长效抗凝剂华法林抗凝效果的影响。方法选择长期服用华法林的血栓栓塞性疾病患者116例,拟服用阿奇霉素的58例作为实验组,未服用阿奇霉素的58例作为对照组。应用国际标准化比值（INR）监测患者治疗后凝血功能的变化。结果实验组患者服用阿奇霉素5d后INR显著增高（用药前1.9±0.3,用药后2.1±0.5,P〈0.05）,有8例（13.8%）患者INR〉2.5的,其中6例为老龄患者。对照组患者治疗前、后INR比较,差异无统计学意义（P〈0.05）。结论阿奇霉素增强华法林抗凝作用,尤其是老年患者。
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| 关 键 词： | 抗凝药 华法林 国际标准化比值 阿奇霉素 |
Influence of azithromycin on anticoagulant effect of warfarin |
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| Wu Wei,Li Yan,Lu Zhibing. Influence of azithromycin on anticoagulant effect of warfarin[J]. International Journal of Laboratory Medicine, 2013, 34(23): 3125-3126 |
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| Authors: | Wu Wei Li Yan Lu Zhibing |
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| Affiliation: | (People＇s Hospital of Wuhan University / Hubei Provincial People＇s Hospital： 1. Department of Clinical Laboratory; 2. Clinical Center for Molecular diagnosis ; 3. Department of Cardiology ,VCuhan , Hubei 430060 ,China) |
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| Abstract: | Objective To investigate influence of azithromycin on effect of long-term anticoagulant warfarin.Methods 116 patients with thromboembolic disease who needed long-term warfarin medication were enrolled.58 patients who needed combination with azithromycin served as experimental group,and the other 58 patients who did not use azithromycin as control group.Interna- tional normalized ratio（INR）was employed to monitor the changes of coagulation function of patients after treatment.Results After 5 d of azithromycin treatment,INR of patients was significantly increased（treatment before：1.9±0.3,treatment after：2.1± 0.5,P〈0.05）,INR2.5 was found in 8（13.8%） patients,and 6 of them were elderly patients.Compared INR of patients in control group between treatment before and after,difference was not statistically significant（P〈0.05）.Conclusion Azithromycin en- hances anticoagulant effect of warfarin,especially in elderly patients. |
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| Keywords: | anticoagulants warfarin international normalized ratio |
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