盐城市盐都区外来务工人员HIV、梅毒、HCV和HBV感染状况调查

目的调查了解盐城市盐都区外来务工人员中人类免疫缺陷病毒（HIV）、梅毒螺旋体（TP）、丙型肝炎病毒（HCV）和乙型肝炎病毒（HBV）感染状况,为在这类人群中开展相关传染病预防控制提供依据。方法采用ELISA法分别检测外来务工人员血清中HIV（1＋2）抗体、TP抗体、HCV抗体和HBsAg;HIV抗体阳性者按技术规范进行复检和确证;TP抗体阳性者用梅毒螺旋体抗体明胶颗粒凝集试验（TPPA）进行复检,确认阳性者再作梅毒快速血浆反应素试验（RPR）;HCV抗体阳性者使用另一厂家试剂复检;HBsAg阳性者作乙肝五项血清标志物检测。结果共检测外来务工人员标本442例,发现HIV感染3例（0.68%）、TP感染10例（2.26%）、HCV感染1例（0.23%）、HBsAg阳性39例（8.82%）,其中HIV和HCV合并感染、TP和HBV合并感染各1例。TP感染者中RPR阳性6例（60.00%）,滴度1∶1-1∶4;HBsAg阳性者中出现6种乙肝＂两对半＂模式,其中以HBsAg、抗HBe、抗HBc阳性为主66.67%（26/39）]。结论盐都区外来务工人员中HIV、HBV、TP感染率均较高,应加大这类人群的监测和干预力度,有效控制相关传染病在人群中的流行。

Investigation on the prevalence of HIV,Syphilis,HCV and HBV among the migrant workers in Yandu District of Yancheng City

Objective To understand the prevalence of human immunodeficiency virus（HIV）,Treponema pallidum（TP）,hepatitis C virus（HCV） and hepatitis B virus（HBV） of the migrant workers in Yandu District of Yancheng City,and to provide a scientific basis for the control and prevention of infectious disease.Methods Serum anti-HIV,anti-TP,anti-HCV and HBsAg of the migrant workers were detected by enzyme linked immunosorbent assay（ELISA）.Positive results of anti-HIV would be repeated and confirmed by western blot.Treponema pallidum particle agglutination（TPPA） assay were carried out on the positive samples of TP antibody,then rapid plasma regain（RPR） were conducted on the positive ones;positive results of anti-HCV would be repeated by another detection reagent;the markers of HBV（HBVM） were detected with the positive samples of HBsAg.Results 442 migrant workers were detected taltally,and 3cases（0.68%） of HIV,10cases（2.26%） syphilis,1 case（0.23%） HCV,39 cases（8.82%） HBsAg were detected respectively.1 case of dual infection with HIV and HCV and 1 case with syphilis and HBV were detected.6 positive cases（60.00%） in syphilis patient were detected with RPR in which the titers were 1∶1-1∶4;6 kinds of infection mode of HBV markers appears in HBsAg positive people and the most common mode was positive HBsAg,anti-HBe and anti-HBc which accounted for 66.67%（26/39）.Conclusion The infection rate of HIV,HBV and TP in migrant workers are high in Yandu District.Comprehensive intervention must be taken to prevent the spreading of AIDS,hepatitis B and syphilis.