| 辛伐他汀对大鼠胫骨骨缺损修复作用的实验研究 |
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| 引用本文： | 刘志强,周磊,邹剑曾,李东健,司徒燕,王继洲.辛伐他汀对大鼠胫骨骨缺损修复作用的实验研究[J].临床口腔医学杂志,2010,26(4):214-217. |
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| 作者姓名： | 刘志强 周磊 邹剑曾 李东健 司徒燕 王继洲 |
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| 作者单位： | 1. 广州市荔湾区口腔医院,广东,广州,510170
2. 广东省口腔医院·南方医科大学附属口腔医院 |
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| 基金项目： | 广东省自然科学基金项目(32569) |
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| 摘 要： | 目的：研究辛伐他汀作为激活物对骨生成的促进作用。方法：通过制备大鼠胫骨骨缺损模型填入Bio-oss骨粉,同时给予口服辛伐他汀（实验组）,并设立空白组、对照组（骨缺损单纯填入Bio-oss骨粉）,于术后4、8、12周分别处死大鼠,进行定性、定量分析,观测骨增量变化。结果：空白组无法形成正常骨愈合;实验组在骨量形成和新骨改建速度方面明显优于对照组。结论：辛伐他汀有促进新骨生成作用。
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| 关 键 词： | 辛伐他汀 骨缺损 成骨作用 |
Experimental study on bone formation in defect of ratstibia by Simvastatin be taken orally |
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| LIU Zhi-qiang,ZHOU Lei,ZOU Jian-zeng,LI Dong-jian,SITU Yan,WANG Ji-zhou.Experimental study on bone formation in defect of ratstibia by Simvastatin be taken orally[J].Journal of Clinical Stomatology,2010,26(4):214-217. |
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| Authors: | LIU Zhi-qiang ZHOU Lei ZOU Jian-zeng LI Dong-jian SITU Yan WANG Ji-zhou |
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| Affiliation: | 1.Liwan District Stomatological Hospital,Guangzhou 510170,China;2.Guangdong Provincial Stomatologycal Hospital Affilianted Stomatologycal Hospital of Soutyern Medical University Guangdong Guangzhou 510280,China. |
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| Abstract: | Objective：To study stimulation of bone formation by statins（simvastatin）as a activation.Method：72 SD rats（3mm defect of left tibia）were random treated with three groups：1.untreated group;2.comparison group：Bio-oss alone be filled in defect of tibia;3.experiment group：compounding simvastatin be taken orally.The rats were sacrificed in 4、8 and 12 weeks and the bone formation was observed.Result：The difference was obvious in 8 and 12 weeks.Compared group 2 and 3,the bone formation of group 3 was better in quality and velocity.Conclusion：Simvastatin as a activation can improve bone formation in defect of rats tibia. |
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| Keywords: | simvastatin defect of tibia bone formation |
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