Structures and functions of the inflammasome engine |
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| Authors: | Longfei Wang Humayun Sharif Setu M. Vora Yumei Zheng Hao Wu |
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| Affiliation: | Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Mass |
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| Abstract: | |
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| Keywords: | Inflammasome NLRP3 NLRP1 NLRC4 pyroptosis IL-1 caspase-1 ADP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" Adenosine diphosphate ASC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" Apoptosis-associated, speck-like protein containing a caspase recruitment domain CARD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" Caspase recruitment domain CARD8" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" CARD-containing protein 8 cryo-EM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" Cryo-electron microscopy CT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0100" }," $$" :[{" #name" :" text" ," _" :" C-terminal DAMP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110" }," $$" :[{" #name" :" text" ," _" :" Damage-associated molecular pattern DPP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110b" }," $$" :[{" #name" :" text" ," _" :" Dipeptidyl peptidase FIIND" },{" #name" :" keyword" ," $" :{" id" :" kwrd0120" }," $$" :[{" #name" :" text" ," _" :" Function-to-find domain GSDMD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0120d" }," $$" :[{" #name" :" text" ," _" :" Gasdermin D HD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130" }," $$" :[{" #name" :" text" ," _" :" Helical domain LRR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130y" }," $$" :[{" #name" :" text" ," _" :" Leucine-rich repeat NACHT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130w" }," $$" :[{" #name" :" text" ," _" :" NAIP, CIITA, HET-E, and TP1 NAIP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140" }," $$" :[{" #name" :" text" ," _" :" NLR family of apoptosis inhibitory protein NBD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140i" }," $$" :[{" #name" :" text" ," _" :" Nucleotide-binding domain NLR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0150" }," $$" :[{" #name" :" text" ," _" :" Nucleotide-binding domain and leucine-rich repeat-containing protein PAMP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0160" }," $$" :[{" #name" :" text" ," _" :" Pathogen-associated molecular pattern PYD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0170" }," $$" :[{" #name" :" text" ," _" :" Pyrin domain UPA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0180" }," $$" :[{" #name" :" text" ," _" :" Conserved in UNC5, PIDD and ankyrins VbP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0190" }," $$" :[{" #name" :" text" ," _" :" Val-boro-pro ZU5" },{" #name" :" keyword" ," $" :{" id" :" kwrd0190t" }," $$" :[{" #name" :" text" ," _" :" Initially found in Zonula occludens-1 and UNC5 |
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