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| 乳腺癌基因环境交互作用的研究进展 | |
| 引用本文： | 江军仪,项永兵,陶梦华,徐望红. 乳腺癌基因环境交互作用的研究进展[J]. 肿瘤, 2011, 31(6): 558-564. DOI: 10.3781/j.issn.1000-7431.2011.06.017 |
| 作者姓名： | 江军仪 项永兵 陶梦华 徐望红 |
| 作者单位： | 1. 复旦大学公共卫生学院流行病学教研室,教育部公共卫生安全重点实验室,上海,200032 2. 上海市肿瘤研究所流行病学研究室,上海,200032 3. 布法罗大学公共卫生与卫生事业学院社会与预防医学系,纽约,14214 4. 复旦大学公共卫生学院流行病学教研室,教育部公共卫生安全重点实验室,上海,200032;上海市肿瘤研究所流行病学研究室,上海,200032 |
| 基金项目： | 国家自然科学基金资助项目 |
| 摘 要： | 乳腺癌是女性最常见的恶性肿瘤之一。基因-环境交互作用(gene-environment interaction,GEI)在乳腺癌发病中的作用一直是人们关注的焦点,早期的研究采用候选基因方法,主要关注代谢酶基因,DNA修复基因和凋亡基因等。近年来,乳腺癌全基因组关联研究(genome-wide association study,GWAS)发现了多个乳腺癌易感基因及位点,为乳腺癌GEI研究提供了广阔的发展前景,并带来了极大的挑战。本文就目前乳腺癌GEI的研究现状及进展进行综述,以揭示进一步研究的趋势和方向。 |
| 关 键 词： | 乳腺肿瘤 危险因素 基因-环境交互作用 |
Advances in research of gene-environment interactions in breast cancer |
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| JIANG Jun-yi,XIANG Yong-bing,TAO Meng-hua,XU Wang-hong. Advances in research of gene-environment interactions in breast cancer[J]. Tumor, 2011, 31(6): 558-564. DOI: 10.3781/j.issn.1000-7431.2011.06.017 | |
| Authors: | JIANG Jun-yi XIANG Yong-bing TAO Meng-hua XU Wang-hong |
| Affiliation: | JIANG Jun-yi1,XIANG Yong-bing2,TAO Meng-hua3,XU Wang-hong1,2 1.Department of Epidemiology,School of Public Health,Fudan University,Key Laboratory of Public Health Safety,Ministry of Education,Shanghai 200032,China,2.Department of Epidemiology,Shanghai Cancer Institute,3.Department of Social and Preventive Medicine,School of Public Health and Health Professions,University at Buffalo,New York 14214,USA |
| Abstract: | Breast cancer is one of the most frequently diagnosed cancers in women.It has been increasingly recognized that breast cancer is a result of interplays between different exposures and host susceptibilities.The study of gene-environment interactions(GEI) has been confined to candidate gene approach which is mainly involving genes related to metabolism,DNA repair,cell apoptosis,etc.Recent genome-wide association studies are identifying novel susceptibility genes of breast cancer.These studies,without any biol... |
| Keywords: | Breast neoplasms Risk factors Gene-environment interaction |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
