| 人端粒酶逆转录酶及其影响因子在乳腺癌中的表达 |
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| 引用本文： | 范春玲,周景华,胡成乙.人端粒酶逆转录酶及其影响因子在乳腺癌中的表达[J].黑龙江医学,2007,31(6):403-405. |
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| 作者姓名： | 范春玲 周景华 胡成乙 |
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| 作者单位： | 黑龙江八一农垦大学,黑龙江,大庆,163319;黑龙江中医药大学附属第一医院,黑龙江,哈尔滨,150040;哈尔滨医科大学第四临床医学院,黑龙江,哈尔滨,150010 |
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| 基金项目： | 黑龙江省农垦总局科研项目 |
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| 摘 要： | 目的 为了研究hTERT（人端粒酶逆转录酶）及其影响因子（P^53和c—myc）在乳腺癌中的表达和意义。方法 用免疫组化SP法在52例乳腺癌和16例乳腺良性瘤中检测了hTERT，P^53和c—myc。结果表明hTERT，P^53和c—myc在乳腺癌组的阳性表达率均显著高于乳腺良性瘤组。统计分析表明，乳腺癌中hTERT蛋白表达阳性率与P^53和c—myc的阳性表达密切相关（P〈0．05）。结论 在乳腺癌的发生中，发生了P^53基因突变和c—myc基因的表达增加，激活了hTERT，从而可能导致了乳腺癌的发生。
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| 关 键 词： | 乳腺癌 人端粒酶逆转录酶 P53 c-myc |
| 文章编号： | 1004-5775（2007）06-0403-03 |
| 修稿时间： | 2007-03-18 |
Expression of hTERT and Its Affecting Factors in Breast Cancer |
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| FAN Chun-ling,ZHOU Jing-hua,HU Chen-yi.Expression of hTERT and Its Affecting Factors in Breast Cancer[J].Heilongjiang Medical Journal,2007,31(6):403-405. |
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| Authors: | FAN Chun-ling ZHOU Jing-hua HU Chen-yi |
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| Affiliation: | The Heilongjiang August - first Agricultural University, Daqing 163319, China |
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| Abstract: | Objective To investigate expression of hTERT(human telomerase reverse transciptase) and its affecting factors in breast cancer,we detected the expression of hTERT,P53 and c-myc in fifty-two samples of breast cancer and sixteen samples of benign breast tumor using immunohistochemical SP method.The expression of hTERT,P53 and c-myc was higher than that of the benign breast tumor group.Analysis showed that the expression of hTERT was obviously correlated with P53 and c-myc in breast cancer(P<0.05).In the development procession of breast cancer,oncogene c-myc was activated and P53 was mutated.This induced the activation of hTERT which might promote the generation of breast cancer. |
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| Keywords: | Breast cancer Human telomerase reverse transciptase P^53 c-myc |
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