| 生血丸1号对免疫介导的再生障碍性贫血小鼠骨髓增殖及细胞周期蛋白D_3表达的影响 |
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| 引用本文： | 王玲玲,周冬枝,刘永惠,于晓原,吴苏冬.生血丸1号对免疫介导的再生障碍性贫血小鼠骨髓增殖及细胞周期蛋白D_3表达的影响[J].中国中西医结合杂志,2003(Z1). |
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| 作者姓名： | 王玲玲 周冬枝 刘永惠 于晓原 吴苏冬 |
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| 作者单位： | 西安交通大学第一医院中医科 西安交大校医院 西安交通大学第一医院中医科 （西安710061） 胜利石油管理局胜中社区供应医院（山东省东营市 257000） （西安710061） |
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| 摘 要： | 目的:探讨生血丸1号(简称生血丸)对免疫介导的再生障碍性贫血(简称再障)小鼠骨髓增殖及细胞周期蛋白 D_3(Cyclin D_3)表达的影响。方法:建立免疫介导的再障模型,胃饲生血丸1号水提液,每次0.1ml/10g 体重,每天2次,连续9天,并以康力隆为对照。第10天处死动物,采用流式细胞仪检测小鼠骨髓有核细胞(BMNC)G_0/G_1期百分率,免疫组织化学超敏 S-AP 法检测股骨中段骨髓 Cyclin D_3表达水平。结果:生血丸组 G_0/G_1期细胞百分率较再障模型组显著降低(P<0.05),而 Cyclin D_3表达水平明显高于再障模型组(P<0.01),两项指标之间呈显著负相关(r=-0.8219,P<0.05)。结论:生血丸1号能提高免疫介导的再障小鼠骨髓 Cyclin D_3的表达水平,从而促进造血细胞由 G_0/G_1期进入增殖期。
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| 关 键 词： | 生血丸1号 再生障碍性贫血 骨髓增殖 细胞周期蛋白 D_3 |
Effect of Shengxue Pill No.1 on Bone Marrow Proliferation and Cyclin D_3 Expression in Immune Induced Aplastic Anemia Mice |
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| Affiliation: | WANG Ling-ling ZHOU Dong-zhi LIU Yong-hui Department of TCM; First Hospital of Xi an Jiaotong University; Xi an(710061); |
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| Abstract: | Objective:To study the influence of Shengxue Pill No.1 (SX1) on bone marrow proliferation and Cyclin D_3 expression in im- mune induced aplastic anemia (AA) mice.Methods:The established model of AA were divided into 2 groups,the treated group and the control group.The former was treated by water extract of SX10.1 ml/10 g body weight,medicated with gastrogavage,twice a day for 9 successive days,and the control group was treated with Kanglilong.Animals were killed on the 10th day,the G_0/G_1 per- centage of b... |
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| Keywords: | Shengxue Pill No 1 aplastic anemia bone marrow proliferation Cyclin D_3 |
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