| 原发性骨小细胞肿瘤的病理形态和免疫组化分析 |
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| 引用本文： | 那加,邹万忠,方志伟,张莹.原发性骨小细胞肿瘤的病理形态和免疫组化分析[J].北京大学学报(医学版),2003,35(1):33-36. |
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| 作者姓名： | 那加 邹万忠 方志伟 张莹 |
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| 作者单位： | 1. 北京大学第一医院病理科,北京,100034
2. 北京大学第一医院骨科,北京,100034 |
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| 摘 要： | 目的：探讨免疫组化染色及病理形态在原发性骨小细胞肿瘤鉴别诊断中的意义。方法：对39例骨的小细胞肿瘤其中尤因肉瘤/外周性原始神经外胚层肿瘤（EW/PNET瘤）22例、小细胞骨肉瘤6例、间叶性软骨肉瘤3例和恶性淋巴瘤8例]，观察其病理形态并作免疫组化分析，所用抗体O13、NSE、S-100、Actin和LCA。结果：EW/PNET瘤20/22例为O13阳性。NSE:EW/PNET瘤16/22例和1例骨肉瘤阳性。7例EW/PNET瘤、1例骨肉瘤及3例间叶性软骨肉瘤均有S-100阳性。所有恶性淋巴瘤的LCA均为阳性。骨肉瘤均见骨样基质，间叶性软骨肉瘤可见分化较好的软骨岛。结论：O13的染色对于EW/PNET瘤有诊断意义。小细胞骨肉瘤的成骨和间叶性软骨肉瘤的软骨分化为形态上的诊断要点。
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| 关 键 词： | 原发性骨小细胞肿瘤 病理形态 免疫组化分析 诊断 |
| 文章编号： | 1671-167X(2003)01-0033-04 |
Pathologic diagnosis of primary small round cell tumors of the bone |
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| Jia Na,Wanzhong Zou,Zhiwei Fang,Ying Zhang.Pathologic diagnosis of primary small round cell tumors of the bone[J].Journal of Peking University:Health Sciences,2003,35(1):33-36. |
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| Authors: | Jia Na Wanzhong Zou Zhiwei Fang Ying Zhang |
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| Affiliation: | Department of Pathology, Peking University First Hospital, Beijing 100034, China. jna4495@hotmail.com |
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| Abstract: | Objective: To study the diagnosis and differentiation of primary small round cell tumors of bone. Methods: Thirty nine cases were studied by light microscopy and immunochemistry of O13,NSE,S 100,Actin and LCA. Results: 20/22 cases of EW/PNET were positive for O13.16/22 cases of EW/ PNET and one case of small cell osteosarcoma were positive for NSE.S 100 was positive in EW/PNET,small cell osteosarcoma and mesenchymal chondrosarcoma. All malignant lymphomas were positive for LCA.6 cases of small cell osteosarcoma have osteoid production. Islands of cartilage were found in mesenchymal chondrosarcoma. Conclusion: O13 is a specific valuable marker for the diagnosis of EW/PNET. Histologic features of the osteoid in osteosarcoma and the cartilage in mesenchymal chondrosarcoma are important for the diagnosis. |
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| Keywords: | Carcinoma small cell/pathol Bone neoplasms/pathol Osteosarcoma/diag |
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