| 一株多重耐药铜绿假单胞菌耐药基因的研究 |
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| 引用本文： | 张景萍,王萍,张全斌,金柳,商润萍,郑新萍,马云霞,周永安.一株多重耐药铜绿假单胞菌耐药基因的研究[J].山西临床医药,2011(2):126-128. |
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| 作者姓名： | 张景萍 王萍 张全斌 金柳 商润萍 郑新萍 马云霞 周永安 |
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| 作者单位： | 太原市中心医院,山西太原030009 |
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| 基金项目： | 山西省卫生厅科技攻关计划项目 |
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| 摘 要： | 目的：研究铜绿假单胞菌多重耐药情况和相关机制。方法：采用聚合酶链式反应（PCR）法对一株多重耐药铜绿假单胞菌进行β-内酰胺酶基因、氨基糖苷类修饰酶基因、氯霉素类基因、耐消毒剂和磺胺类基因检测。结果：PCR结果显示该株PA的TEM,MIR,CTX-M1群,OXA-1群,OXA-10群,aac（6′）-b,aac（6′）-,aac（3）-,ant（2″）-,catB,qacE△1-sul1基因均为阳性,GES,DHA,VEB,cmlA基因均阴性,Opr D2未缺失。结论：该株铜绿假单胞菌存在多重耐药基因,而且对胺类、胍类消毒剂耐受。
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| 关 键 词： | 铜绿假单胞菌 β-内酰胺类 氨基糖苷类 耐药基因 |
Study on the strain of pseudomonas aeruginosa with multi-drug resistance gene |
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| ZHANG Jing-ping,WANG Ping,ZHANG Quan-bin,JIN Liu,SHANG Run-ping,ZHENG Xin-ping,MA Yun-xia,ZHOU Yong-an.Study on the strain of pseudomonas aeruginosa with multi-drug resistance gene[J].Shanxi Clinical Medicine,2011(2):126-128. |
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| Authors: | ZHANG Jing-ping WANG Ping ZHANG Quan-bin JIN Liu SHANG Run-ping ZHENG Xin-ping MA Yun-xia ZHOU Yong-an |
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| Affiliation: | (The Central Hospital of Taiyuan,Taiyuan 030009,China) |
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| Abstract: | Objective：To study the instance and mechanism of multi-drug resistance of pseudomonas aeruginosa.Methods：The genes of multi-drug resistance including beta-lactamase,aminoglycosides modifying enzymes,chloramphenicol,disinfect resistance and sulfanilamide-resistance were determined by polymerase chain reaction（PCR）.Results：The results of PCR indicated that TEM,MIR,CTX-M1,OXA-1,OXA-10,aac（6′）-Ⅰb,aac（6′）-Ⅰ,aac（3）-Ⅱ,ant（2″）-Ⅰ,catB,qacE △1-sul1 genes were positive,while GES,DHA-2,VEB,cmlA genes were negative,Opr D2 is not missing.Conclusion：There are multi-drug resistance genes in the strain of pseudomonas aeruginosa,which resist disinfectant of amines and guanidines. |
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| Keywords: | pseudomonas aeruginosa beta-lactamase aminoglycosides drug resistant gene |
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