Clinical and genetic correlates of severity in schizophrenia in India: an ordinal logistic regression approach期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Clinical and genetic correlates of severity in schizophrenia in India: an ordinal logistic regression approach

Authors:	Thomas Pramod Chandra Abha Bhatia Triptish Mishra N N Sharma Vikash Ranjan Gauba Deepak Wood Joel Chowdari Kodavali Semwal Prachi Thelma B K Nimgaonkar Vishwajit L Deshpande Smita N

Affiliation:	^a Training Program for Psychiatric Genetics in India, Dr RML Hospital, New Delhi, India ^b Meerut College, C.C.S University, Meerut- U.P, India ^c Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA ^d Department of Genetics, University of Delhi South Campus, New Delhi-110021, India ^e Department of Human Genetics, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA ^f Department of Psychiatry, PGIMER-Dr. Ram Manohar Lohia Hospital, New Delhi, India

Abstract:	Genetic association studies of schizophrenia typically utilize diagnostic status as the trait of interest. Among Indian schizophrenia (SZ) participants, we evaluated genetic associations (selected single nucleotide polymorphisms (SNPs) associated with SZ) with selected indices of severity and symptom pattern. Ordinal logistic regression enabled us to analyze variables with multiple categories as outcome variables, while incorporating key demographic variables; this form of analysis may be useful in future genetic association studies. No significant associations were detected following corrections for multiple comparisons.

Keywords:	Schizophrenia Genetics Severity
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