丁苯酞联合马来酸桂哌齐特对急性脑梗死患者脑血流及神经功能相关指标水平的影响

目的 观察丁苯酞软胶囊联合马来酸桂哌齐特注射液对急性脑梗死患者脑血流、神经功能及炎性指标等的影响.方法 选取2017年3月—2018年3月海南省干部疗养院/海南省老年病医院内科收治急性脑梗死患者100例,按照随机数字表法分为对照组和观察组,各50例.对照组给予马来酸桂哌齐特注射液治疗,观察组在此基础上给予丁苯酞软胶囊治...

Effect of butylphthalide combined with cinepazide maleate on cerebral blood flow and neurological function related indexes in patients with acute cerebral infarction

Objective To observe the effects of butylphthalide soft capsule combined with Cinepazide maleate injection on cerebral blood flow,nerve function and inflammatory indexes in patients with acute cerebral infarction.Methods From March 2017 to March 2018,100 patients with acute cerebral infarction were admitted to the Department of Internal Medicine of Hainan Provincial Cadre Sanatorium/Hainan Provincial Geriatrics Hospital.According to the random number table,they were divided into control group and observation group,with 50 cases in each.The control group was treated with cinepazide maleate injection,and the observation group was treated with butylphthalide soft capsule on this basis.Comparison of the treatment effects of the two groups.The blood flow speed of the middle cerebral artery(MCA),anterior cerebral artery(ACA),nerve growth factor(NGF)and neuron-specific enolase(NSE)of the two groups before treatment and 14 days after treatment),brain-derived neurotrophic factor(BDNF),astrocyte-derived protein(S100-β),tumor necrosis factorα(TNF-α),C-reactive protein(CRP),interleukin 10(IL-10),monocytes Chemotactic protein 1(MCP-1)levels,and compare the ADL score,NIHSS score,and adverse reactions during treatment.Results After treatment,the total effective rate of treatment in the observation group was significantly higher than that in the control group(96.00%vs.80.00%,χ²/P=6.061/0.014).After treatment,the blood flow speed of MCA and ACA,serum NGF,BDNF,and IL-10 levels,ADL scores were higher than before treatment,NSE,S100-β,TNF-α,CRP,MCP-1 levels,and NIHSS scores were all lower than before treatment(P<0.05).MCA and ACA blood flow speed and serum levels of patients in the observation group after treatment NGF,BDNF,IL-10 levels,ADL scores are all higher than the control group(t/P=4.450/0.001,4.317/0.001,3.315/0.001,10.420/0.001,6.274/0.001,7.507/0.001),NSE,S100-β,The levels of TNF-α,CRP,MCP-1,and NIHSS scores were all lower than those of the control group(t/P=7.963/0.001,5.212/0.001,13.450/0.001,14.840/0.001,11.650/0.001,6.385/0.001).Conclusion Butylphthalide soft capsule combined with cinepazide maleate injection is effective in the treatment of patients with acute cerebral infarction.It can improve cerebral blood flow,promote the recovery of brain nerve function of patients and inhibit inflammatory reaction by regulating the levels of NGF,NSE and BDNF.To achieve the purpose of treatment.