人参皂苷抗高脂血症及动脉粥样硬化的实验研究

目的:探讨人参皂苷防治高脂血症、动脉粥样硬化的疗效与可能的机制。方法:给C57/BL-ApoE基因敲除小鼠喂饲胆固醇饲料90天,形成实验性高胆固醇血症和动脉粥样硬化斑块,同时中药治疗组连续给人参皂苷喂养90天,实验结束后测量小鼠血脂,观察动脉壁的光镜改变。结果显示:人参皂苷能抑制血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)的上升。结论:说明人参皂苷能治疗实验性高脂血症,抑制动脉粥样硬化斑块的形成。

Experimental Study of Ginsenoside on Inhibiting Hyperlipemia and Atherosclerosis

To observe the effect of Ginsenoside on lipid-metabolism and aortic intimal atherosclerotic plaque coverage in C57/BL-ApoE mouse's model of experimental hyperlipemia and atherosclerosis.Sixty-four mice were randomized into four groups: control group,fed with common diet for 90 days;Hypercholesterolemia group,Ginsenoside(TCM) group and Lovastatin group,fed with 1% cholesterol for 90 days.At the same time in TCM group and Lovastatin group,Ginsenoside and Lovastatin were given for 90 days.The plasma Level oftriglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C) were measured by the end of experiment.Light microscope were adopted to assess the degree of pathologic damage of arterial wall.Ginsenoside could reduce the levels of plasma TC,LDL-C as compared with the Hypercholesterolemia group.It could reduce aortic intimal lipid.It's proved that Ginsenoside can inhibit experimental hyperlipemia and reduce the area of atherosclerotic plaques.