| 决明子对实验性大鼠糖尿病肾病疗效观察 |
| |
| 引用本文： | 李龙,杨明正,陈应强,曾家顺,吴仲明. 决明子对实验性大鼠糖尿病肾病疗效观察[J]. 中国中西医结合杂志, 2005, 0(Z1) |
| |
| 作者姓名： | 李龙 杨明正 陈应强 曾家顺 吴仲明 |
| |
| 作者单位： | 贵阳医学院附属医院肾内科 贵阳550004 |
| |
| 基金项目： | 贵州省教委基金(F2000-5)，贵州省省长基金(S20001-8) |
| |
| 摘 要： | 目的观察决明子对实验性大鼠糖尿病肾病(diabetic nephropathy,DN)治疗作用,并探讨其可能机制。方法32只雄性SD大鼠随机分成4组,即正常对照组、模型组、低、高剂量决明子治疗组,每组8只。模型组及治疗组采用STZ 60mg/kg体重一次性腹腔注射,正常对照组注射等量枸椽酸缓冲液。治疗组予决明子按低剂量10 g·kg~(-1)·d~(-1)与高剂量50g·kg~(-1)·d~(-1)水煎灌胃,对照组及模型组喂予等量饮用水。各组疗程均为8周。分别采用酶联免疫吸附(enzyme-linked immunosorbent assay,EUSA)法测定各组大鼠外周血单个核细胞(peripheral blood mononuclear cells,PBMC)中核因子-κB(nuclear factor kappa B,NF-κB)活性；免疫组化检测各组肾组织NF-κB、纤粘蛋白(fibronectin,FN)的表达；光镜观察肾组织形态。结果与模型组比较,决明子明显抑制NF-κB活化和FN表达,减少24h尿蛋白排泄,降低血脂及肌酐水平,减轻肾小球肥大、系膜细胞增生和细胞外基质堆积。结论决明子对DN具有明显...
|
| 关 键 词： | 糖尿病肾病 大鼠 NF-KB 决明子 |
Efficacy Observation of Cassia Seed on Diabetic Nephropathy of Experimental Rats |
| |
| LI Long YANG Ming-zheng CHEN Ying-qiang. Efficacy Observation of Cassia Seed on Diabetic Nephropathy of Experimental Rats[J]. Chinese journal of integrated traditional and Western medicine, 2005, 0(Z1) |
| |
| Authors: | LI Long YANG Ming-zheng CHEN Ying-qiang |
| |
| Abstract: | Objective To observe the treatment of Cassia Seed (CS) on diabetic nephropathy of experimen- tal rats and to explore its possible mechanism.Methods Thirty-two male SD rats were randomly divided into 4 groups,i.e.the normal control,model,low dose of CS treated and high dose of CS treated group.Streptozotocin (STZ),60 mg/kg body weight,was once peritoneally injected to rats in the model and the treated groups,while equal volume of citric acid buffer liquid to rats in the normal control group.CS water decoctio... |
| |
| Keywords: | diabetic nephropathy rats nuclear factor kappa B Cassia Seed |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
