阿罗洛尔对比RAS阻断剂对中青年高血压患者动脉僵硬度影响的初步研究

目的 不同的降压药物对血管的影响不同,本研究试图探讨具有血管扩张作用的B受体阻滞剂阿罗洛尔（Arotinolol）对中青年高血压患者动脉僵硬度的影响.方法 选中青年高血压无合并症和靶器官损害初诊患者87例,分为普通治疗组（RAS阻断剂或联用钙拮抗剂）（42例）和阿罗洛尔组（阿罗洛尔或联合钙拮抗剂）（45例）,进行降压治疗,并控制血压达标,分别在治疗前、治疗后3个月、6个月检查患者的血压、心率、肱踝脉搏波传导速度（baPWV）和踝臂指数（ABI）,比较治疗前后的变化情况.结果 阿罗洛尔组较非阿罗洛尔组相比,能够明显降低患者心率（P＜0.05）和舒张压（P＜0.05）.两组血压控制达标后,肱踝脉搏波传导速度（baPWV）均较治疗前明显降低（P＜0.05）,随着血压的稳定,baPWV未再有进一步的变化,而两组之间的baPWV之间相比无统计学差异,治疗前后ABI变化不明显.结论 阿罗洛尔有更好的降低舒张压的作用,控制血压可以使baPWV降低,但不影响ABI;以阿罗洛尔为主的降压治疗与CCB加RAS阻断剂组相比动脉僵硬度改变相似.

Preliminary Study of Arotinolol vs RAS Inhibitors on the Arterial Rigidity of Young and Middle Aged Hypertensives

Objective Various antihypertensive drugs have different effects on blood vessel,which is the important target organ damaged by hypertension.The present report elucidates the effect of Arotinolol（a vasodilating beta-blocker） on conductive arteries in young hypertensives.Methods Totally 87 young patients without target-organ damage and concomitant disease were divided to 2 treating group：CCB combined with RAS antagonists（42 patients） and Arotinolol with CCB（45 patients）.All blood pressure was well controlled.BaPWV and ABI were measured by BP-203RPE Ⅱ device before,3 month after and 6 month after anti-hypertension treatment.Results Treatment with Arotinolol had a more lowering effect in heart rate（P ＜ 0.05） and diastolic BP（P ＜ 0.05）.baPWV was lowered after BP control in both group（P ＜ 0.05）,with the same rgetextent in both group,and with no significant difference between the two group.There were no obvious change in ABI with BP lower,in both group.Conclusion Arotinolol had a better effect in lower heart rate and diastolic BP.Lowering of BP can cause baPWV slow,but do not affect ABI.Arotinolol had the same effect on arterial stiffness with CCB and RAS antagonist.