益髓生血颗粒夏季治疗地中海贫血患者57例临床观察

目的探讨补肾益髓法夏季治疗中间型地中海贫血临床疗效。方法选取具有相同中医证候（肝肾阴虚精血不足证），不同基因型的两种中间型地中海贫血患者（α-，β-型），用补肾益髓法的代表方益髓生血颗粒加麦冬进行治疗，采用安慰剂平行对照方法，疗程3个月，动态观察患者中医证候、疗效性血液指标（H11、RBC、Ret、HbF）、患者血清及红细胞抗氧化指标（SOD、MDA、GSH—PX）、血清造血相关细胞因子（SCF、GM—CSF、IL-3）活性的变化。结果与治疗前比，治疗组患者主要疗效性血液指标血红蛋白（Hb）自疗程第1～3个月疗程结束均有升高（P〈0．05），而安慰剂组无明显改善；中医证候量化评分统计结果显示，治疗组α-地中海贫血患者临床表现面色萎黄、头晕盗汗、手足心热、爪甲色淡等症状疗后明显减轻（P〈0．05），而安慰剂组疗效不明显；治疗组β-地中海贫血患者临床表现食少纳呆、潮热盗汗、手足心热等临床症状，治疗后症状明显减轻（P〈0．05）；与治疗前比，治疗组患者血清SOD疗后有上升（P〈0．05）、红细胞SOD治疗后有上升（P〈0．05）；对血清造血相关细胞因子活性检测结果显示，治疗组SCF和GM—CSF治疗后较治疗前有上升趋势，但无统计意义。结论益髓生血颗粒加麦冬治疗夏季地中海贫血患者贫血，对同一证候（肝肾阴虚、精血不足证）不同基因型的两种地中海贫血（α-型，β-型）患者均有明显疗效，在夏季应用益髓生血颗粒加麦冬治疗地贫符合中医临床不同季节适时辩证施治特点，有助于改善患者贫血状况，提高生存质量。

Clinical Observation on 57 Thalassemia Patients Treated by Yisuishengxue Granul in Summer

Objective To study the clinical effect of ＂Yisuishengxue＂ for the treatment of inter - mediate - thalassemia patients in summer. Methods We selected thalassemia patients who had the same traditional Chinese medicine syndrome but with two different gene type（α-,β-type）, and then randomized them into two groups. Patientsin the treatment group was treatmeb by YisuiShengxue Granul （YSSXG） adding maidong（ Radix Ophiopogonis） ,while those in the control group were given placebo. The whole course of treatment was three months,then we observed their traditional Chinese medicine syndromes and the blood parameters as Hb, RBC, Ret, HbH,and detec- ted the SOD, MDA, GSH - PX from blood serum as well as red blood cells, also the activity of SCF, GM - CSF, IL - 3 from blood serum. Results Hb of the treatment group had ascended after treatment（P 〈 0.05）. The placebo group had no definete effect. The traditional Chinese medicine syndromes（Sallow complexion, dizziness,feverishness in palms and soles etc） of α-,thalassemia patients in treatment group had relived （ P 〈 0.05 ）. The placebo group had no definete effect. The syndromes （ not feel like eating, night sweats, feverishness in palms and soles etc） of β- thalassemia patients in treatment group had relived（P 〈0.05）. SOD from serum in treatment group had rised after treatment（P 〈 0.05 ） , and the SOD from the red blood cells had rised after treatment（ P 〈 0.05 ） , while the resuh of the activity about SCF and GM - CSF just had a upward trend,but no statistic meaning. Conclusion There is a definete effect in treating the two types of thalassemias by YSSXG adding maidong（ Radix Ophiopogonis）. Using YSSXG adding maidong to treat patients in summer,conforms to the principle ＂different therapies with different syndroms in different seasons＂ from chinese tradional medicine,and improves the anemia syn- dromes so as to enhance the quality of patientss life.