马来酸依那普利叶酸片对H型高血压患者同型半胱氨酸的影响

目的 分析马来酸依那普利叶酸片对H型高血压患者同型半胱氨酸(homocysteine,Hcy)的影响,旨在探讨临床治疗该病的有效疗法,促进患者尽早康复。 方法 选取金华市中心医院2018年9月—2019年9月诊治的86例H型高血压患者,按照入院先后顺序分成A组(43例)与B组(43例),分别运用马来酸依那普利片与马来酸依那普利叶酸片治疗,比较2组患者的血压水平(收缩压、舒张压)、降压效果、Hcy水平以及颈动脉彩超检查结果(颈总动脉内-中膜厚度、颈动脉斑块面积)。 结果 B组治疗后的收缩压、舒张压(119.5±9.2)mm Hg、(79.5±7.0)mm Hg]均低于A组(136.3±10.4)mm Hg、(87.1±8.3)mm Hg],差异有统计学意义(t=7.934、4.590,均P<0.05);B组降压效果的总有效率(93.0%,40/43)高于A组(76.7%,33/43),差异有统计学意义(χ2=4.440,P<0.05);B组治疗后的Hcy水平(10.5±3.3)μmol/L]低于A组(13.8±3.6)μmol/L],差异有统计学意义(t=4.431,P<0.05);B组治疗后的颈总动脉内-中膜厚度、颈动脉斑块面积(1.13±0.16)mm、(19.87±1.82)mm2]均小于A组(1.19±0.17) mm、(21.79±1.89)mm2],差异有统计学意义(t=1.685、4.798,均P<0.05)。 结论 马来酸依那普利叶酸片治疗H型高血压的疗效理想,可降低患者血压与Hcy水平,且可改善颈动脉彩超检查结果,降压效果的总有效率高,有助于稳定患者病情,促使其尽早康复。 

Effect of enalapril maleate folate tablets on Hcy in patients with H-type hypertension

Objective To analyze the effect of enalapril maleate folate tablets on homocysteine(Hcy) in patients with H-type hypertension, in order to explore the effective treatment of the disease and promote the early recovery of patients. Methods A total of 86 patients with H-type hypertension diagnosed and treated in our hospital from September 2018 to September 2019 were divided into group A(43 cases) and group B(43 cases) according to the sequence of admission. Enalapril maleate tablets and enalapril maleate folate tablets were used for treatment respectively, and the blood pressure level(systolic and diastolic pressure), blood pressure reduction effect, Hcy level and carotid ultrasonography results(Intima-media thickness and plaque area of common carotid artery) of the two groups were compared. Results The systolic blood pressure and diastolic blood pressure of group B(119.5±9.2) mm Hg,(79.5±7.0) mm Hg] were lower than those of group A(136.3±10.4) mm Hg,(87.1±8.3) mm Hg], the difference were statistically significant(t=7.934, 4.590, all P<0.05). The total effective rate of group B(93.0%, 40/43) was higher than that of group A(76.7%, 33/43), the difference is statistically significant(χ2=4.440, P<0.05). The Hcy level of group B(10.5±3.3) μmol/L] was lower than that of group A(13.8±3.6) μmol/L], the difference is statistically significant(t=4.431, P<0.05). The intima-media thickness and carotid plaque area of group B(1.13±0.16) mm,(19.87±1.82) mm2] were lower than those of group A(1.19±0.17) mm,(21.79±1.89) mm2], the difference is statistically significant(t=1.685, 4.798, all P<0.05). Conclusion Enalapril maleate folate tablets have ideal therapeutic effect in the treatment of H-type hypertension, can reduce the water pressure and Hcy level of patients, and can improve the results of carotid ultrasonography, the total effective rate of hypotensive effect is high, which is helpful to stabilize patients' condition and promote their early recovery, which is worthy of clinical implementation.