自体牙本质颗粒联合富血小板血浆对引导骨再生治疗牙周骨缺损的效果分析

目的 探讨自体牙本质颗粒联合富血小板血浆治疗牙周骨缺损的效果。 方法 选取宁波口腔医院2016年10月—2018年2月收治的84例上颌前部单颗牙齿缺失伴水平骨缺损需进行单颗种植及引导骨再生治疗的患者,将患者分为研究组和对照组,每组42例。对照组术中植入Bio-oss人工骨粉,研究组术中植入自体牙本质颗粒联合富血小板血浆。分别于T0(手术前)、T1(术后2周)、T2(术后1年)等时间点对患者口腔进行锥形束CT (CBCT)检查,通过评测CBCT图像横截面口腔软组织情况,分析对比2组患者颊侧软组织剖面、颊侧骨厚度、颊侧软组织厚度、修复成功率、并发症发生情况及红色美学评分的差异。 结果 2组颊侧软组织剖面、颊侧骨厚度、颊侧软组织厚度组间比较、时点间比较及分组与时间的交互作用差异均有统计学意义(均P<0.05)。T1时刻,研究组颊侧骨厚度比对照组大(P<0.05)。T2时刻,研究组颊侧软组织剖面比对照组大(P<0.05),2组颊侧骨厚度、颊侧软组织厚度比较差异无统计学意义(均P>0.05)。术后1年,2组患者修复成功率、并发症发生率、红色美学评分组间比较差异无统计学意义(均P>0.05)。 结论 自体牙本质颗粒联合富血小板血浆对于引导骨再生治疗牙周骨缺损有显著疗效,满足上前牙单颗种植牙的美学要求。 

Effect of autogenous dentin particles combining platelet rich plasma on guided bone regeneration in the treatment of periodontal bone defect

Objective To investigate the effect of autogenous dentin particles combining platelet rich plasma in treatment of periodontal bone defect. Methods A total of 84 cases of single tooth loss and horizontal bone defect in the anterior maxilla require single implantation and guided bone regeneration patients in our hospital from October 2016 to February 2018 were divided into research group(42 cases) and control group(42 cases). The patients in research group received autogenous dentin particles combining platelet rich plasma, while the patients in control group received connective tissue graft re-establish treatment. All patients were tested by the Cone Bean Computed Tomographies(CBCT) at following time: T0(before surgery), T1(2 weeks after surgery), and T2(1 year after surgery). The buccal soft tissue profile(BSP), buccal bone thickness(BB), buccal soft tissue thickness(BST), repair success rate, complication rate, and pink esthetic score(PES) of the two groups were compared. Results There were statistically significant differences in BSP, BB, and BST between the two groups and time points(all P<0.05). The BB of the control group was larger than that of the research group at T1(P<0.05). The BSP of the research group at T2 was larger than that of the control group(P<0.05), and there was no significant difference in BB, BST between two groups(all P>0.05). There was no significant difference in repair success rate, complication rate and PES between the two groups(all P>0.05). Conclusion Autogenous dentin particles combined with platelet rich plasma have significant efficacy in guiding bone regeneration for the treatment of periodontal bone defects, doing well in aesthetic requirements of single anterior implants.