| 不同糖耐量者血清游离脂肪酸与胰岛素抵抗的关系 |
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| 引用本文： | 马慧娟,宋光耀,王智华,张文杰,冯志山,马博清,叶蔚,杨爽.不同糖耐量者血清游离脂肪酸与胰岛素抵抗的关系[J].中华内分泌代谢杂志,2003,19(3):228-229. |
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| 作者姓名： | 马慧娟 宋光耀 王智华 张文杰 冯志山 马博清 叶蔚 杨爽 |
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| 作者单位： | 050051,石家庄,河北省老年医学研究所,河北省人民医院 |
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| 基金项目： | 河北省卫生厅科研基金(01052) |
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| 摘 要： | 以口服糖耐量试验(OGTT)确定受试者为正常人,糖耐量低减(IGT)和2型糖尿病,并测定空腹和OGTT 2h的游离脂肪酸(FFA)、血糖和胰岛素浓度,计算胰岛素敏感指数(IAI)。2型糖尿病和IGT患者的空腹和OGTT 2 h FFA、血糖和胰岛素浓度均明显高于正常组(均P<0.05),IAI均明显低于正常对照组(均P<0.01)。空腹及OGTT 2 h FFA与IAI之间呈显著负相关(分别为r=-0.38,P<0.01和r=-0.32,P<0.05),体重指数与IAI呈显著负相关(r=-0.39,P<0.05)。上述结果提示脂毒性在2型糖尿病的发病机制中有重要作用。
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| 关 键 词： | 2型糖尿病 糖耐量低减 游离脂肪酸 血糖 胰岛素 胰岛素抵抗 |
| 修稿时间： | 2001年11月23 |
Relation between serum free fatty acids and insulin resistance in subjects with different glucose tolerances |
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| MA Hui-juan,SONG Guang-yao,WANG Zhi-hua,ZHANG Wen-jie,FENG Zhi-shan,MA Bo-qing,YE Wei,YANG Shuang. Hebei institute of Geriatrics,Hebei provincial people's hospital,Shijiazhuang.Relation between serum free fatty acids and insulin resistance in subjects with different glucose tolerances[J].Chinese Journal of Endocrinology and Metabolism,2003,19(3):228-229. |
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| Authors: | MA Hui-juan SONG Guang-yao WANG Zhi-hua ZHANG Wen-jie FENG Zhi-shan MA Bo-qing YE Wei YANG Shuang Hebei institute of Geriatrics Hebei provincial people's hospital Shijiazhuang |
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| Affiliation: | MA Hui-juan,SONG Guang-yao,WANG Zhi-hua,ZHANG Wen-jie,FENG Zhi-shan,MA Bo-qing,YE Wei,YANG Shuang. Hebei institute of Geriatrics,Hebei provincial people's hospital,Shijiazhuang 050051 |
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| Abstract: | Subjects with normal glucose tolerance, impaired glucose tolerance (IGT) and type 2 diabetes were identified by oral glucose tolerance test (OGTT). Free fatty acid (FFA) , plasma glucose and insulin were determined in the fasting and 2 h blood samples during OGTT, and insulin action index (IAI) was calculated. The levels of fasting and OGTT 2 h FFA, plasma glucose and insulin in the subjects with type 2 diabetes and IGT were significantly higher than those in normal subjects (all P < 0. 05) and IAI significantly lower than that in normal subjects (P<0.01). The fasting and OCTT 2 h FFA were negatively correlated with IAI ( r = -0.38, P < 0. 01 and r = - 0. 32 , P <0. 05 respectively) and body mass index also showed significantly negative correlation with IAI ( r = - 0. 39 , P < 0. 05 ). These results suggest that lipotoxicity plays an important role in the pathogenesis of type 2 diabetes. |
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| Keywords: | Diabetes mellitus non-insulin-dependent Impaired glucose tolerance Fatty acid nonesterified |
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