莲必治注射液致肾功能损害56例文献分析

目的:探讨莲必治注射液致肾损害的特点和规律,为临床安全用药提供参考。方法:对2000-2011年国内医药期刊报道的莲必治注射液致56例肾损害病例的性别与分布,既往过敏史,出现时间、原患疾病、用药情况、主要临床表现、治疗方法及预后等进行统计分析。结果:56例莲必治注射液致肾功能受损事件中,男性、女性患者分别占73.21%和26.79%,年龄为14～66岁,大多在用药1～2次后出现,及时停药并给予治疗,预后一般良好,单独或联合用药均可发生。结论:临床应重视莲必治注射液致肾功能损害事件的发生。尽量做到用药全程监护,以减少不良反应的发生。

Literature Analysis of 56 Cases of Renal Injury Induced by Lianbizhi Injection

OBJECTIVE: To discuss the characteristics and regularity of the renal injury induced by Lianbizhi injection, and to provide a reference for the safety of drug use in the clinic. METHODS: 56 cases of renal injury induced by Lianbizhi injection, which were reported in the domestic medicine journal from 2000 to 2011, were analyzed statistically in respect of sex and distribution, allergy history, occurrence time, original disease, drug use condition, main clinical manifestation, therapy method and prognosis. RESULTS: In these 56 cases, male and female patients respectively accounted for 73.21% and 26.79%, whose age were between 14 and 66. Most of them appeared after using the drug 1 or 2 times, then stopped taking drug in time and were given treatment. The prognosis was sound usually. Either alone or drug combination resulted in renal injury. CONCLUSIONS: We should pay attention to Lianbizhi injection-induced renal injury and take care of the whole drug use process to reduce the occurrence of adverse drug reactions.