补肾活血中药复方对脑缺血性损伤的保护作用

用复方中药给家兔灌饲７ｄ后,分别测兔脑缺血３０ｍｉｎ及再灌流６０ｍｉｎ、１２０ｍｉｎ时脑组织中ＬＰＯ舍量、ＳＯＤ活力;另给“血瘀”家兔模型灌饲该中药７ｄ后测血液流变学变化。结果：该中药能显著降低脑缺血后再灌流１２０ｍｉｎ时脑组织ＬＰＯ含量、保护ＳＯＤ活力、降低全血粘度、抑制ＡＤＰ诱导的血小板聚集,提示该中药可保护兔脑缺血性损伤。作用机理：①抗氧自由基损伤;②通过降低血浆纤维蛋白原含量降低全血粘度。

THE PROTECTIVE EFFECTS OF TCM ON CEREBRAL ISCHEMIA

In order to study the protective effects of traditional chinese medicine (TCM ) thathave effects of tonicizing the kidney, invigorating qiand promoting the blood circulation to remove stasis, we made the model of rabbit cerebral ischemiafor 30 min and reperfusion for 60 min and 120 minsrespectively after the rabbits were fed with theTCM for 7 days and we assessed cerebral tissue levels of MDA and SOD activity. We measured thehemorrheologic property after the rabbits of themodel of "blood stasisll were fed with the TCM for7 days. The results showed that the TCM decreasedsignificantly the MDA of cerebral tissue and protected SOD activity when rabbitswere in the state ofbrain reperfusion for 120 min. The whole-blood viscosity in model of" blood stasis" declined. Theplatelet aggregation resulted from ADP were alsoprevented. The present experiments demonstratedthat the TCM exerted protective effects on acutecerebral ischemea and reper fusion injury of rabbits.The underlying mechanisms were thought as follows: ① The TCM plays the role of resisting insultof oxygen free radicals to cerebral tissue. ② TheTCM may reduce the whole-blood viscosity.