吲哚菁绿荧光法在乳腺癌前哨淋巴结活检中的临床效果研究

目的观察和分析吲哚菁绿(ICG)荧光法在乳腺癌前哨淋巴结活检中的临床效果。方法 60例疑似乳腺癌患者作为研究对象,分别行美蓝染色法和吲哚菁绿荧光法检测。对比分析两种检测方法的检测结果 ,并以病理检查结果为金标准比较两种检测方法的假阴性率、准确率;平均检测用时和前哨淋巴结转移数量。结果病理检查结果显示阳性40例、阴性20例。吲哚菁绿荧光法的准确率95.00%(57/60)高于美蓝染色法的75.0%(45/60),假阴性率5.00%(2/40)低于美蓝染色法的20.00%(8/40),差异均有统计学意义(P<0.05)。吲哚菁绿荧光法的平均检测用时(11.25±1.12)min短于美蓝染色法的(17.26±1.53)min,前哨淋巴结转移数量(3.21±0.76)枚多于美蓝染色法的(1.79±0.52)枚,差异均有统计学意义(P<0.05)。结论吲哚菁绿荧光法应用于乳腺癌前哨淋巴结活检中,能降低假阴性率,提高诊断准确性,值得临床推广应用。

Analysis on the clinical effect of indocyanine green fluorescence in sentinel lymph node biopsy of breast cancer

Objective To observe and analyze the clinical effect of indocyanine green(ICG) fluorescence in sentinel lymph node biopsy of breast cancer. Methods A total of 60 suspected breast cancer patients as study subjects all detected by methylene blue staining and indocyanine green fluorescence. The detection results of the two methods were compared. With pathological examination results as gold standard, the false negative rate, the accuracy rate, the success rate, the average detection time and the number of sentinel lymph node metastases of the two methods were compared. Results Pathological examination showed that 40 cases were positive and 20 cases were negative. The accuracy rate and detection success rate of indocyanine green fluorescence were 95.00%(57/60) and 98.33%(59/60) respectively, which were higher than 75.0%(45/60) and 88.33%(53/60) of methylene blue staining, and false negative rate 5.00%(2/40) was lower than 20.00%(8/40) of methylene blue staining. Their difference was statistically significant(P<0.05). The average detection time(11.25±1.12) min of indocyanine green fluorescence was shorter than(17.26±1.53) min of methylene blue staining, and number of sentinel lymph node metastases(3.21±0.76) pieces was more than(1.79±0.52) pieces of methylene blue staining. Their difference was statistically significant(P<0.05). Conclusion The application of indocyanine green fluorescence in sentinel lymph node biopsy of breast cancer can reduce the false negative rate and improve the accuracy of diagnosis, which is worthy of clinical promotion and application.