| H5亚型禽流感灭活疫苗免疫后鸡血凝抑制抗体动态变化观察 |
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| 引用本文： | 刘梅,龚建森,李文良,徐玲霞,戴亚斌,刘学贤,徐步. H5亚型禽流感灭活疫苗免疫后鸡血凝抑制抗体动态变化观察[J]. 中国家禽, 2005, 9(Z1): 136-138 |
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| 作者姓名： | 刘梅 龚建森 李文良 徐玲霞 戴亚斌 刘学贤 徐步 |
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| 作者单位： | 1. 中国农业科学院家禽研究所,江苏,扬州,225003
2. 扬州市畜牧兽医站,江苏,扬州,225009 |
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| 基金项目： | 江苏省社会发展计划项目(BS2004003) |
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| 摘 要： | 选择国家指定的两个厂家生产的禽流感灭活疫苗(H5亚型,N28株)进行无母源抗体来航鸡的免疫试验.通过鸡免疫后血凝抑制(HI)抗体的动态性检测,对两个疫苗的免疫效果进行了观察.研究结果表明,两个疫苗均具有良好的免疫效果,但也存在一定程度的差异;加强免疫可以明显提高抗体水平,延长免疫保护时间.
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| 关 键 词： | 禽流感 疫苗 免疫 血凝抑制试验 抗体效价 |
| 修稿时间： | 2005-11-16 |
Hemagglutination Inhibition Antibody Responses to Inactivated Oil-emulsion Vaccines Against H5 Subtype Avian Influenza Virus |
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| Liu Mei,Gong Jiansen,Li Wenliang,Xu Lingxia,Dai Yabin,Liu Xuexian,Xu Bu. Hemagglutination Inhibition Antibody Responses to Inactivated Oil-emulsion Vaccines Against H5 Subtype Avian Influenza Virus[J]. China Poultry, 2005, 9(Z1): 136-138 |
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| Authors: | Liu Mei Gong Jiansen Li Wenliang Xu Lingxia Dai Yabin Liu Xuexian Xu Bu |
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| Abstract: | In present study,white Leghorn chickens without maternal antibodies were immunized with inactivated oil-emulsion vaccines (H5 subtype,N28 strain) against H5 subtype avian influenza vims produced by two licensed vaccine manufacturers in China following manufacturer's recommendation,and the immunization efficacies of two vaccines were evaluated based on the antibody levels measured by haemagglutination inhibition (HI) test. The results showed that both vaccines induced good HI antibody responses, but little difference existed. Booster immunization could elicit higher HI antibody titer and prolong the period during which the HI antibody titer was equal to or higher than the lowest protective antibody titer of 1:16. |
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| Keywords: | avian influenza vaccine immunization heraagglutination inhibition (HI) test antibody titer |
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