| 白芍总甙的抗惊厥作用 |
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| 引用本文： | 张艳,明亮,王瑜,马红星,马传庚,徐叔云.白芍总甙的抗惊厥作用[J].中国药理学通报,1994(5). |
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| 作者姓名： | 张艳 明亮 王瑜 马红星 马传庚 徐叔云 |
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| 作者单位： | 安徽医科大学药理教研室，合肥经济技术学院医院 |
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| 摘 要： | 采用最大电休克发作（ＭＥＳ）法、士的宁惊厥法和戊血氮最小阈发作（ＭＥＴ）法，观察白芍总甙（ＴＧＰ）对动物惊厥的影响。实验结果表明，ＴＧＰ（２０～８０ｍｇ·ｋｇ－１·ｄ－１，ｉｐ和ｉｇ×３ｄ）呈剂量依赖性对抗小鼠的ＭＥＳ。ＴＧＰ（６０～１００ｍｇ·ｋｇ－１·ｄ－１，ｉｐ）能对抗士的宁引起的小鼠和大鼠的惊厥。ＴＧＰ（４０～８０ｍｓ·ｋｇ－１·ｄ－１，ｉｐ）对小鼠的ＭＥＴ无影响。ＴＧＰ（４０～８０ｍｇ·ｋｇ－１·ｄ－１，ｉｐ）对小鼠ＭＥＳ的作用高峰时间在０．５～１．５ｈ之间。
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| 关 键 词： | 白芍总甙，最大电休克发作，士的宁，惊厥，戊四氮最小阈发作 |
Anticonvulsant action of total glucosides of paeony root |
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| ZHANG Yan,MING Liang,WANG Yu et al.Anticonvulsant action of total glucosides of paeony root[J].Chinese Pharmacological Bulletin,1994(5). |
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| Authors: | ZHANG Yan MING Liang WANG Yu |
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| Abstract: | The anticonvulsant action of Total Glucosides of Paeony Root(TGP) was investigated in Maximal electroshock Seizure(MES),strychinine-induced convulsion and Metrazol Minimal threshold Seizure(MET), respectively. The results showed that TGP(20￣80 mg·kg-1·d-1, ip and ig×3d)had a dose-dependent protective effect against MES in mice and TGP (60￣100mg·kg-1· d- 1,ip)also had an antagonism to strychinine-induced convulsion in botn mice and rats, but it(40￣80 mg·kg-1,ip)did not influence MET in mice.In addition,the Peak time of anticonvulsant action of TGP(40￣80 mg·kg-1, ip)against MES in mice was at 0.5￣1.5 h after administration of this drug. |
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| Keywords: | total glucosides of paeonyroot maximal electroshock seizure strychinine-induced convulsion metrazol minimal threshold seizure |
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