血府逐瘀汤对荷瘤小鼠的抑瘤作用

目的：观察血府逐瘀汤对荷瘤小鼠免疫功能的影响，探讨血府逐瘀汤的抗肿瘤效果及其抗肿瘤的免疫学机制。方法：小鼠造模后给予不同药物治疗，10d后观察药物对瘤重和脾细胞功能的影响。结果：血府逐瘀汤能够显著抑制瘤重，活化T淋巴细胞增殖能力，提高荷瘤小鼠脾脏L3T4^ 细胞数量，升高L3T4^ ／Lyt-2^ 细胞比值，促进IL-2的分泌，但对Lyt-2^ 细胞数量影响不大。结论：血府逐瘀汤能够完全逆转肿瘤抗原和环磷酰胺引起的免疫抑制，其抑瘤作用与增强机体细胞免疫功能有关。

EFFECTS OF XUE FU ZHU YU DECOCTION ON IMMUNE FU NCTION OF TUMOR-BEARING MICE

Objective:To investigate the effects of XueFuZhuYu Decoction(XFZYD)on immune Function of Tumor-bearing mice and its antineoplastic effective mechanismMethods:taking S 180-bearing mice as an amimal model and treated by different medicament,the effect of XFZYD on tumor weight and immunologic function of S 180-bearing mice were observed systematicallyResults:XFZYD can decrease tumor weight and promote proliferation of activated T cell ,the number of L 3T 4 cell,the ratio of L 3T 4+/Tyt-2+and IL-2 levels in S 180-bearing mice,but it had little effect on the number of Lyt-2+ cellConclusions:XFZYD can primarily increase the number of Th1 cell and IL-2 levels,meanwhile it can completely reverse the immunological inhibition caused by tumor antigen and cylophosphamideIt was suggested that the effect of tumor-inhibition by XFZYD results from the enchancing of the celluler immunity