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| HPLC同时测定莪术油及其注射液中3种成分的含量 | |
| 引用本文： | 袁文娟,田颂九,张启明,李慧义,崔友.HPLC同时测定莪术油及其注射液中3种成分的含量[J].中国药学杂志,2008,43(3):168-170. |
| 作者姓名： | 袁文娟 田颂九 张启明 李慧义 崔友 |
| 作者单位： | 1. 中国药品生物制品检定所,北京,100050;云南省食品药品检验所,昆明,650011 2. 中国药品生物制品检定所,北京,100050 3. 浙江天瑞制药股份有限公司,浙江,瑞安,325200 |
| 摘 要： | 目的建立同时测定莪术油注射液中3种成分含量的方法。方法采用VP-ODSC18柱(4.6mm×250mm,5μm)。流动相:0.1%磷酸水溶液-乙腈(梯度洗脱),流速1.0mL·min-1,检测波长:210nm。结果4种成分线性关系良好,r>0.9997,平均回收率均大于99.0%,RSD均小于2.0%。结论该方法准确、灵敏度高,可作为制剂质量控制。 |
| 关 键 词： | 莪术油注射液 莪术二酮 莪术醇 =牛儿酮 高效液相色谱法 |
| 文章编号： | 1001-2494（2008）03-0168-03 |
| 收稿时间： | 2006-12-20 |
| 修稿时间： | 2006年12月20 |
Determination of Four Constituents in Oleum Curcumae And Zedoary Turmeric Oil Injection by HPLC |
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| YUAN Wen-Juan,TIAN Song-Jiu,ZHANG Qi-ming,LI Hui-yi,CUI You.Determination of Four Constituents in Oleum Curcumae And Zedoary Turmeric Oil Injection by HPLC[J].Chinese Pharmaceutical Journal,2008,43(3):168-170. | |
| Authors: | YUAN Wen-Juan TIAN Song-Jiu ZHANG Qi-ming LI Hui-yi CUI You |
| Affiliation: | 1.National Institute for the Control of Pharmaceutical and Biological Products，Beijing 100050，China；2.Yunnan Provincial Institute for Foodstuff & Drug Control，Kunming 650011，China；3.Zhejiang Tianrui Pharmaceutical Co.Ltd，Ruian 325200，China |
| Abstract: | OBJECTIVE To establish a HPLC method for the determination of three constituents curdione,curcumol and germacrone in zedoary turmeric oil injection.METHODS The sample was analyzed on SHIMADZU VP-ODS C18(4.6 mm×250 mm,5 μm)column with mobile phase consisting of 0.1% phosphoric acid and acetonitrile by gradient eluteion at the flow rate of 1.0 mL·min-1.The wavelength was at 210 nm.RESULTS The good linearity,recovery and reproducibility were obtained.The mean recoveries were above 99.0% and RSDs were below 20%.CONCLUSION The method is simple,quick to process and accurate,and can be used for quality control for zedoary turmeric oil injection. |
| Keywords: | zedoary turmeric oil injection curdione cureumol germacrone HPLC |
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