三种结核抗体对肺结核的诊断价值

目的:探讨3种结核抗体试剂盒对肺结核的诊断价值。方法:采用澳大利亚产ICT-TB卡、TB—DOT和国产快速ELISA试剂盒检测220例肺结核,菌阳者60例,菌阴者160例,与48例非结核肺疾病和30例健康人对比观察。结果:220例肺结核血清结核抗体敏感性ICT-TB卡为50.7%、TB-DOT为60.0%、ELISA为68.2%,三者间差异具有显著性(P<0.05)。菌阳组分别为76.7%、80.0%、88.3%,菌阴组50.0%、52.5%、60.6%,菌阳与菌阴者间均有显著差异(P<0.005)。3种结核抗体特异性为98.7%、91.0%、84.6%,差异显著(P<0.025)。结论:抗原纯度较高的ICT-TB卡,TB-DOT特异性较强,但敏感性较低,复合抗原ELISA敏感性较好,但特异性偏低。

Value of three kinds of tuberculosis antibody in diagnosis of tuberculosis

Objective To study the value of three kinds of tuberculosis antibody in diagnosis of pulmonary tuberculosis.Method by ICT-TB card,TB-DOT produced in Australia and domestic ELISA,tuberculosis antibodies of 220patients with pulmonary tubercu-losis,60cases of the smear positive and160cases of the smear negative were detected and observed comparatively with48cases of non-tuberculosis lung disease and30healthy individuals.Results The sensitivity of 220patients with pulmonary tuberculosis ICT-TB card was50.7%,TB-DOT 60.0%,ELISA68.2%,there was significant difference(P<0.05),the sensitivity of the smear positive group76.7%,80.0%,88.3%,the smear negative group was50.0%,52.5%,60.0%,there were significant difference between the two groups(P<0.005).The specificity of three kinds tuberculosis antibody were98.7%,91.0%,84.6%,there was significant difference(P<0.025).Con clu-sion The specificity of ICT-TB card and TB-DOT is higher,but the sensitivity is lower.On the contrary,the sensitivity of ELISA is higher but the specificity is lower.