1例重症患者抗感染个体化给药策略分析

目的 探讨对于重症感染的患者如何根据其特殊的病理生理状况制订个体化抗感染治疗方案。方法 临床药师参与1例急性泛发性发疹性脓疱病继发血流感染和肺部感染患者的抗感染治疗，通过分析其病理生理状况，运用治疗药物监测，协助临床医生制订个体化的给药方案。结果 患者初始抗感染治疗方案效果不佳，临床药师根据患者的个体情况和血药浓度监测结果调整给药方案，患者的感染得到控制，病情好转。结论 确保重症患者给药剂量达到药动学/药效学目标值是治疗成功的关键。

The individualized anti-infective treatment strategy for a critically ill patient

Objective To design individualized anti-infective therapy for a critically ill patient.Methods Based on pathophysiological conditions and therapeutic drug levels,clinical pharmacists assisted physicians to optimize individual anti-infective medication regimens for a patient with acute generalized exanthematous pustulosis secondary to blood stream infection and pulmonary infection.Results The patient responded poorly to initial treatment. After the medication regimen adjustments byclinical pharmacists according to the individual situation and therapeutic drug monitoring results,patient''s condition was improved and the infection was under control. Conclusion The key to successful treatment is to ensure the dosage administered to the critically ill patients reach the target value of pharmacokinetics and pharmacodynamics.