丹参多酚酸盐治疗冠心病心绞痛的效果及其对血液流变学和氧化应激的影响评价

目的探索丹参多酚酸盐治疗冠心病心绞痛的效果及其对血液流变学及氧化应激的影响。方法选取2018-03至2019-03住院治疗的243例估计合格的冠心病心绞痛患者作为试验对象,根据2010年新版CONSORT指南进行人群排除,120例符合者采用随机数字表法分为对照组(n=60)和观察组(n=60)。对照组行常规治疗,观察组在对照组基础上加入丹参多酚酸盐治疗,均治疗14 d。对比两组左室射血分数(left ventricular ejection fraction,LVEF)、左室收缩末期容积(end-systolic volume,ESV)、左室舒张末期容积(end diastolic volume,EDV)、心绞痛持续时间、心绞痛发作频率、总抗氧化力(total antioxidative capacity,TAC)、脂质过氧化物(lipid peroxide,LPO)、超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)、红细胞聚集指数、血浆黏度、全血黏度低切、全血黏度高切、总有效率。结果观察组心绞痛发作频率为(0.33±0.19)次/周,低于对照组(P<0.05),心绞痛持续时间为(1.23±0.56)min/次,短于对照组(P<0.05),总有效率为96.67%,高于对照组(P<0.05);TAC(12.89±2.45)kU/L、LPO(3.02±0.56)μmol/L、SOD(84.69±5.88)U/L、MDA(2.05±0.39)μmol/L、红细胞聚集指数(2.11±0.35)%、血浆黏度(1.07±0.05)mpa.s、全血黏度低切(7.16±0.52)mpa.s、全血黏度高切(5.32±0.59)mpa.s、LVEF(51.79±8.95)%、ESV(21.54±2.65)ml、EDV(51.44±4.68)ml均优于对照组(P<0.05)。结论对冠心病心绞痛患者实施丹参多酚酸盐治疗效果显著,利于改善氧化应激状态和血液流变学指标。

Evaluation for the treatment effect of salvianolate and its influence on the hemorheology and oxidative stress in angina pectoris patients

Objective To explore the treatment effect of salvianolate and its influence on the hemorheology and oxidative stress in angina pectoris patients.Methods After filtering of 243 angina pectoris patients based on the new 2010 version of CONSORT Guide,120 of them were divided into the control group and the study group according to the random number table method,60 cases in each group.All patients in two groups were given conventional therapy for 14 days,and the patients in the study group received Salvianolate additionally.Then left ventricular ejection fraction(LVEF),end-systolic volume(ESV),end diastolic volume(EDV),persistence time and frequency of angina pectoris,total antioxidative capacity(TAC),lipid peroxide(LPO),superoxide dismutase(SOD),malondialdehyde(MDA),aggregation index of RBC,plasma viscosity,whole blood viscosity at low shear rate,whole blood viscosity at high shear rate,and the total effective rate were compared between the two groups.Results The angina frequency in the study group were(0.33±0.19)times per week,lower than that in the control group(P<0.05).The single seizure duration in the study group were(1.23±0.56)minutes each time,which was less than that in the control group(P<0.05).And the total effective rate was 96.67%,which was higher than that in the control group(P<0.05).Other items such as TAC(12.89±2.45)kU/L,LPO(3.02±0.56)μmol/L,SOD(84.69±5.88)U/L,MDA(2.05±0.39)μmol/L,aggregation index of RBC(2.11±0.35)%,plasma viscosity(1.07±0.05)mpa.s,whole blood viscosity at low shear rate(7.16±0.52)mpa.s,whole blood viscosity at high shear rate(5.32±0.59)mpa.s,LVEF(51.79±8.95)%,ESV(21.54±2.65)ml,EDV(51.44±4.68)ml,were all better than those in the control group(P<0.05).Conclusions The treatment effect of salvianolate in treating angina pectoris patients is significant.It has advantages in improving the status of oxidative stress and the indexes of hemorheology.