| NEUTROPHIL INFILTRATION IS INVOLVED IN 5-FLUOROURACIL INDUCED LIPID PEROXIDATIVE DAMAGE OF THE SMALL INTESTINE |
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| 引用本文： | 陈冬利,吴国生,王为忠,王俊义. NEUTROPHIL INFILTRATION IS INVOLVED IN 5-FLUOROURACIL INDUCED LIPID PEROXIDATIVE DAMAGE OF THE SMALL INTESTINE[J]. 中国医学科学杂志(英文版), 1997, 12(3): 181-183 |
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| 作者姓名： | 陈冬利 吴国生 王为忠 王俊义 |
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| 作者单位： | Department of Gastroenteric Surgery，Xijing Hospital，Fourth MilitaryMedical University，Xii an 710032 |
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| 摘 要： | INTRODUCTION5-fluorouracil(5-FU)hasbeenusedextensivelyintreatmentofthecommonmalignancies.Becauseofitstoxicdamagetovitalhosttissues,suchasbonemarrowandintestine,thedrughastobeadministratedatadosagewhichisusuallyprovedtobeinsufficienttoeradicatealltheneoplasticcellspresent(1).ltwasre-portedthatlipidperoxidationinliverandbloodmaypartiallycontributetothetoxicside-effectsof5-FU(2,3).Whetheritmayalsoinducelipidperoxidativedam-ageinthesma1lintestineisstillunclear.Thepurposeofthisstudywastoevalu…
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| 关 键 词： | 嗜中性白细胞 5-氟尿嘧啶 脂蛋白酶 小肠 动物实验 药物毒性 |
NEUTROPHIL INFILTRATION IS INVOLVED IN 5-FLUOROURACIL INDUCED LIPID PEROXIDATIVE DAMAGE OF THE SMALL INTESTINE |
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| Chen Dongli ,Wu Guosheng,Wang Weizhong , Wang Junyi. NEUTROPHIL INFILTRATION IS INVOLVED IN 5-FLUOROURACIL INDUCED LIPID PEROXIDATIVE DAMAGE OF THE SMALL INTESTINE[J]. Chinese medical sciences journal, 1997, 12(3): 181-183 |
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| Authors: | Chen Dongli Wu Guosheng Wang Weizhong Wang Junyi |
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| Affiliation: | Department of Gastroenteric Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032. |
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| Abstract: | This study evaluated the mechanisms of 5-fluorouracil (5-FU) induced intestinal damage by investigating the lipid peroxide (LPO) level, myeloperoxidase (MPO) activity and disaccharidase activity in rats. Group I animals (n = 6) were sacrificed and served as a normal control group. Group II animals (n = 24) were given a single intraperitoneal injection of 5-FU (150 mg/kg) and every 8 rats were sacrificed on day 1, 3 and 5 after injection respectively. RESULTS: LPO concentration in blood and intestinal mucosa was significantly higher in the group II than in the group I on day 1 and 3 (P < 0.05). MPO activity was significantly higher in the group II than in the group I at different times (P < 0.01). Lactase activity on day 5 (P < 0.01); sucrase activity (P < 0.01 and P < 0.05 respectively) and maltase activity (P < 0.01) on day 3 and 5, were significantly lower in the group II than in the group I. CONCLUSION: The results indicate that neutrophil infiltration may be involved in 5-FU-induced lipid peroxidative damage of the small intestine which was reflected by the decreased disaccharidases activities. |
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| Keywords: | neutrophil 5-fluorouracil lipid peroxide |
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