泛耐药鲍曼不动杆菌对消毒剂抗药性分析

目的探讨泛耐药鲍曼不动杆菌（PDR—AB）对普通消毒剂的抗药性。方法应用K-B法进行抗菌药物敏感性试验，筛选出鲍曼不动杆菌泛耐药菌株5株，采用纸片法和肉汤培养进行消毒剂敏感试验。结果泛耐药鲍曼不动杆菌对0．5％聚维酮碘（PVP．I）、0．1％醋酸氯己定溶液（洗必泰）、即配0．2％三氯异氰尿酸、2％强化戊二醛（浸泡）敏感性好，而对75％乙醇、0．1％-氧化氯、0．1％PVP-I和配制30min后0．2％三氯异氰尿酸等不敏感。结论0．5％PVP-I、0．1％醋酸氯己定溶液、即配0．2％三氯异氰尿酸、2％强化戊二醛（浸泡）对PDR-AB具有良好的杀灭效果，推荐采用；而低浓度含碘、含氯消毒剂以及75％乙醇效果差，不宜采用。

Drug resistance of pan-drug resistant Acinetobacter baumannii to disinfectants

Objective To investigate the drug resistance of pan-drug resistant Acinetobacter baumannii（PDR-AB） to common disinfectants. Methods K-B paper method was used in routine drug susceptibility test. Paper method and broth cultivation were used in disinfectants susceptibility test. Results The PDR-AB was sensitive to 0.5% povidone iodine （PVP-I） disinfectant,0.1% chlorhexidine acetate solution, 2000ppm trichlorosocynuric acid （freshly prepared）, and 2% glutaraldehyde（soak）, but resistant to 75% ethanol, 0.1% chlorine oxide, 0.1% PVP-I, and 2000ppm trichlorosocynuric acid（prepared 30 minutes later）. Conclusion The 0.5% PVP-I disinfectant, 0.1% chlorhexidine acetate solution, 2000ppm trichlorosocynufic acid （freshly prepared）, and 2% glutaraldehyde（soak） show excellent efficacy in killing clinically isolated PDR-AB, but low concentration of PVP-I and chlorine-containing disinfectants and 75% ethanol show poor efficacy.