结肠癌中miR-135b、miR-141的检测意义

目的 探讨miR-135b、miR-141在结肠癌中的表达以及与肿瘤临床特征之间的相关性。方法 分析2013年2月—2014年5月在上海市闸北区市北医院普通外科接受手术治疗切除的结肠癌及正常结肠组织标本。比较结肠癌与正常结肠组织的miR-135b、miR-141表达差异,并探讨在结肠癌中miR-135b、miR-141的表达与其临床特征的相关性。结果 本研究共纳入结肠癌患者42例和正常结肠组织标本42例。结肠癌组织的miR-135b、miR-141表达均显著高于正常结肠组织(P＜0.01);不同的Dukes分期、分化程度、淋巴结转移情况以及浸润深度所对应的结肠癌组织的miR-135b表达之间的差异均具有统计学意义(P＜0.05);不同的Dukes分期、分化程度、淋巴结转移情况以及浸润深度所对应的结肠癌组织的miR-141表达之间的差异均具有统计学意义(P＜0.05);miR-135b与miR-141的表达水平呈正相关(r=0.611,P=0.023)。结论 miR-135b、miR-141与结肠癌的发生、发展有着密切的联系。

The differential expressions of miR-135b,miR-141 in colorectal carcinoma

Objective Our retrospective study is aimed to analyze the correlative clinical features of be-tween expressions of miR -135b and miR-141 in colorectal cancer.Methods Clinical data and specimens of patients with colorectal carcinoma at our hospital from 2013 to 2014 were retrospectively collected .The expres-sions of miR-135 b and miR-141 between colon cancer and matched normal colonic tissues were compared .The correlation between the expressions of miR -135 b and miR-141 in colorectal carcinoma and the clinical charac-teristics were discussed .Results A total of 42 patients was retrospective analyzed .The expressions of miR -135b,miR-141 in the colon cancer tissues were obviously higher than that in the normal colonic tissues .The differences of the expression of miR -141 in the colon cancer tissues of different Dukes stages ,degree of differen-tiation,lymph node metastasis and infiltration depth were all significant .The expressions of miR -135 b and miR-141 displayed a positive linear correlation .Conclusion The expressions of miR-135b,miR-141 in colorec-tal cancer are significantly increased ,and the expressions display a remarkable correlation with the Dukes stages , degree of differentiation ,lymph node metastasis and infiltration depth of tumor .The expressions of miR-135 b and miR-141 demonstrate a positive correlation .