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| HIFU非热效应诱导兔肝VX2肿瘤损伤 | |
| 引用本文： | 何炜,王维,周平,周鹏.HIFU非热效应诱导兔肝VX2肿瘤损伤[J].中国医学影像技术,2010,26(12):2235-2238. |
| 作者姓名： | 何炜 王维 周平 周鹏 |
| 作者单位： | 1. 中南大学湘雅三医院超声科,湖南,长沙,410013 2. 中南大学湘雅三医院放射科,湖南,长沙,410013 3. 深圳市第二人民医院超声科,广东,深圳,518035 |
| 摘 要： | 目的 探讨高强度聚焦超声(HIFU)非热效应机制诱导兔肝VX2肿瘤损伤的效果及其特点。方法 将22只兔肝VX2肿瘤模型随机分为热效应组(n=11)和非热效应组(n=11),在实时测温下行不同参数HIFU辐照,分别诱导热效应和非热效应损伤,结合病理学检查和辐照剂量对肿瘤的损伤情况对比分析。结果 热效应组和非热效应组的时间-温度曲线分别表现为"快速升高、缓慢下降"和"缓慢升高、缓慢下降",损伤体积分别为(1.10±0.22)cm3和(1.21±0.24)cm3(P＞0.05)。辐照区域伴有不同程度的并发症,两组比较差异无统计学意义(P＞0.05);热效应组和非热效应组残瘤率分别为72.73%和18.18%(P＜0.05);破坏最大血管管径分别为(135.27±22.09)μm和(877.64±253.68)μm(P＜0.001)。与热效应组比较,非热效应组的辐照点数明显降低、辐照时间缩短、总时间延长(P均＜0.001),两组间损伤效率差异无统计学意义(P＞0.05)。结论 HIFU非热效应可有效损伤兔肝VX2肿瘤及其滋养血管。 |
| 关 键 词： | 高强度聚焦超声 兔 肝肿瘤 非热效应 |
| 收稿时间： | 8/5/2010 12:00:00 AM |
| 修稿时间： | 9/8/2010 12:00:00 AM |
Injury on rabbit hepatic VX2 tumor induced by non-thermal effects of high-intenstiy focused ultrasound |
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| HE Wei,WANG Wei,ZHOU Ping and ZHOU Peng.Injury on rabbit hepatic VX2 tumor induced by non-thermal effects of high-intenstiy focused ultrasound[J].Chinese Journal of Medical Imaging Technology,2010,26(12):2235-2238. | |
| Authors: | HE Wei WANG Wei ZHOU Ping and ZHOU Peng |
| Affiliation: | Department of Ultrasound, the Third Xiangya Hospital of Central South University, Changsha 410013, China;Department of Radiology, the Third Xiangya Hospital of Central South University, Changsha 410013, China;Department of Radiology, the Third Xiangya Hospital of Central South University, Changsha 410013, China;Department of Ultrasound, the Third Xiangya Hospital of Central South University, Changsha 410013, China;Department of ultrasound, Shenzhen Second Hospital, Shenzhen 518035, China |
| Abstract: | |
| Keywords: | High-intensity focused ultrasound Rabbits Liver neoplasms Non-thermal effects |
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