大剂量血管加压素在心肺复苏中的应用观察

目的 研究大剂量血管加压素在心肺复苏中的疗效.方法 47例心跳停搏患者随机分为3组,肾上腺素标准剂量组(A组)17例,血管加压素40u+标准剂量肾上腺素组(B组)14例,大剂量血管加压素80U+标准剂量.肾上腺素组(C组)16例.各组分别观察自主循环恢复率、存活率、自主循环恢复时间.结果 A组、B组、C组自主循环恢复率分别为17.6%、50%、56.3%,B组、C组明显高于A组,C组存活率(31.3%)显著高于A组(5.9%)、B组(14.3%);B组、C组的自主循环恢复时间明显短于A组.结论 心肺复苏期间,联合应用大剂量血管加压素和肾上腺素比单独应用标准剂量肾上腺素、血管加压素40U+标准剂量肾上腺素能显著缩短自主循环恢复时间,提高自主循环恢复率和存活率.

Study the effects of high dose vasopressin on cardiopulmonary resuscitation

Objoctive To study the effect of high dose vasopressin on cardiopulmonary resuscitation. Methods 47 patients with cardiac arrest were randomly divided into standard dose epinephrine group (group A, n=17), vasopressin 40 U and standard dose epinephrine group (group B, n=14) and vasopressin 80 U and standard dose epinephrine group (group C, n=16).The rate of spontaneous circulation restoration, the survival rate and the average time of spontaneous circulation restoration were monitored in each group. Results The rates of spontaneous circulation restoration of group A, group B and group C were respoctively 17.6%, 50.0% and 56.3 %. Among them, the rates of spontaneous circulation restoration of group B and group C were significantly higher than that of group A. The survival rate of group C (31.3%) was significantly higher than that of the other two groups (5.9% of group A, 14.3 % of group B). The average time of spontaneous circulation restoration of group B, C was significantly shorter than that of group A. Conclusions Compared with the single administration of standard dose epinephrine or vasopressin 40U and standard dose epinephrine, the administration of high dose vasopressin 80U combined with standard dose epinephrine could significantly shorten the average time of spontaneous circulation restoration, increase the rate of spontaneously circulation restoration and the survival rate during cardiopulmonary resuscitation.