| 22-降-豆甾-22-含氮化合物的合成及抗肿瘤活性 |
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| 引用本文： | 杨雷,范良华,赵丹丹,戚斌斌,甘春芳,崔建国,黄燕敏.22-降-豆甾-22-含氮化合物的合成及抗肿瘤活性[J].应用化学,2015,32(3):0-0. |
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| 作者姓名： | 杨雷 范良华 赵丹丹 戚斌斌 甘春芳 崔建国 黄燕敏 |
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| 作者单位： | 广西师范学院化学与生命科学学院;福建三明市永安共青团 |
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| 基金项目： | 广西教育厅自然科学基金重点基金(201202ZD059)资助~~ |
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| 摘 要： | 通过结构改造，合成了不同支链的甾体化合物并测定了它们的抗肿瘤细胞增殖活性，探讨了不同支链对抗肿瘤活性的影响。
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| 关 键 词： | 22-降-豆甾-22-含氮化合物 抗肿瘤活性 合成. |
| 收稿时间： | 2014-06-10 |
Synthesis and Antiproliferative Activity of 22-Abeo-stigmast-22-nitrogen-containing Compounds |
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| YANG Lei;FAN Lianghua;ZHAO Dandan;QI Binbin;GAN Chunfang;CUI Jian’guo;HUANG Yanmin.Synthesis and Antiproliferative Activity of 22-Abeo-stigmast-22-nitrogen-containing Compounds[J].Chinese Journal of Applied Chemistry,2015,32(3):0-0. |
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| Authors: | YANG Lei;FAN Lianghua;ZHAO Dandan;QI Binbin;GAN Chunfang;CUI Jian’guo;HUANG Yanmin |
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| Abstract: | Using stigmasterol as a starting material, 3β-acetoxycholest-5-ene-22-al was obtained by the protection of 3-hydroxyl and 5-double bond prior to the ozonolysis of 22-ene. Some 22-abeo-stigmast-22-nitrogen-containing compounds were synthesized by the condensation of aldehydes with semicarbazides and thiosemicarbazides. The structure of compounds were confirmed with NMR, IR and MS. Their antiproliferative activities against six kinds of cancer cells were evaluated with MTT method. Compound 8 with the 22-thiosemicarbazone group exhibits significant inhibitory activity on MGC 7901, Hela, SMMC 7404 and CNE-2 cells with the IC50 values of 10.5, 11.6, 8.7 and 11.9 μmol/L, respectively. |
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| Keywords: | 22-abeo-stigmast-22-nitrogen-containing compounds antiproliferative activity synthesis |
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