乌司他丁对脓毒症患儿炎性反应和肾功能的影响

目的:研究鸟司他丁对脓毒症患儿炎性反应和肾功能的影响.方法:42例脓毒症患儿随机数余数分组法分为实验组21例和对照组21例,实验组给予乌司他丁1.2万U/kg一次性加入生理盐水100 mL中静脉滴注,连用7d,对照组以等量生理盐水代替,7d后检测肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-10(IL-10)和尿素氮(BUN)、肌酐(Cr)的变化.结果:实验组血清TNF-α、IL-6浓度明显低于对照组(P＜0.01),IL-10水平高于对照组(P＜0.05)；实验组BUN、Cr水平降低(P＜0.05),对照组BUN、Cr水平无明显变化(P＞0.05).结论:鸟司他丁能降低脓毒症患儿TNF-α、IL-6水平,升高IL-10,减轻炎性反应,同时对肾功能有一定保护作用.

Effect of Ulinastatin on Inflammatory Response and Renal Function in Children with Sepsis

Objective: To study the clinical effects of ulinastain on inflammatory response and renal function in children with sepsis.Methods: Forty two cases of children with sepsis were randomly divided into an experimental group(n=21) and a control group(n=21).The experimental group was given ulinastatin 12,000 U/kg in 100 mL saline for intravenous infusion once a day for 7 days,while the control group was replaced with saline.After treatment for 7 days,tumor necrosis factor alpha(TNF-α),interleukin 6(IL-6),interleukin 10(IL-10) and blood urea nitrogen(BUN),and creatinine(Cr) were measured.Results: The serum TNF-α level and IL-6 concentration of experimental group were significantly lower than those of control group(P<0.01),and IL-10 level was significantly higher than that of control group(P<0.05).In experimental group BUN and Cr decreased significantly(P<0.05),while in control group BUN and Cr level did not change significantly(P>0.05).Conclusions: Ulinastatin can decrease the level of IL-6 and TNF-α,increase the level of IL-10 and protect renal function.