术后早期肠外联合肠内营养支持治疗对老年胃癌病人临床预后的影响

目的:观察术后早期肠外联合肠内营养支持治疗对老年胃癌病人临床预后的影响。方法:96例老年胃癌病人随机分为观察组和对照组,每组48例。术后分别行肠外营养(PN)+肠内营养(EN)和PN支持,持续7 d。测定两组病人手术前后血清C反应蛋白(CRP)、清蛋白(ALB)、转铁蛋白(TF)水平和术后疲劳指数,并观察两组病人术后肛门排气、并发症和住院时间的变化。结果:与对照组比,观察组老年胃癌病人术后第7天血清CRP水平和疲劳指数均明显下降(P<0.05),血清TF水平显著增加(P<0.05),并且术后肛门排气和术后住院时间缩短(P<0.05),术后感染发生率降低(P<0.05)。结论:PN联合EN治疗有助于调节老年胃癌病人术后机体的创伤应激,促进病人康复。

The effect of early postoperative parenteral nutrition combined with enteral nutrition support on the prognosis of gastric cancer in old patients

Objective: To investigate the effects of early postoperative parenteral and enteral nutrition on the prognosis of gastric cancer in old patients.Methods: Ninty six cases of old patients with gastric cancer were randomly divided into treatment group(n=48) and control group(n=48).Parenteral nutrition or enteral nutrition combined with parenteral nutrition were given respectively.The treatment lasted 7day posteroperatively.Serum CRP levels,postoperative fatigue index and serum albumin(ALB)levels and transferrin(TF)levels were measured before and after operation.The prognosis of the disease were compared between these two groups.Results: Compared with the control group,the serum CRP levels(P<0.05)and fatigue index(P<0.05) on 7 d after operation were significantly lower in treatment group.The enteral nutrition combined with parenteral nutrition increased serum transferrin levels(P<0.05),reduced the incidence of postoperative infections(P<0.05),shortered postoperative hospital stay(P<0.05).Conclusion: Parenteral nutrition combined with enteral nutrition can reduce surgical trauma stress and improve surgical prognosis of gastric cancer in old patients.