| HPLC法测定麻杏口服液中苦杏仁苷的含量 |
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| 引用本文： | 李翔,刘皈阳,马建丽,周亮.HPLC法测定麻杏口服液中苦杏仁苷的含量[J].解放军药学学报,2013(1):57-59. |
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| 作者姓名： | 李翔 刘皈阳 马建丽 周亮 |
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| 作者单位： | 解放军总医院第一附属医院药剂药理科 |
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| 摘 要： | 目的建立HPLC法测定麻杏口服液中苦杏仁苷的含量。方法色谱柱：Agilent Eclipse XDB-C18（4.6 mm×150 mm,5μm）;流动相：甲醇-水（20∶80）;流速：1.0 ml.min-1;检测波长：210 nm;柱温：室温;进样量：10μl。结果苦杏仁苷在4.344～217.2μg.ml-1范围内与其峰面积线性关系良好（r=0.9999）,平均回收率为102.08%,RSD为1.75%。结论本方法简便准确、快速可靠,能够用于麻杏口服液的含量测定和质量控制。
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| 关 键 词： | 麻杏口服液 苦杏仁苷 HPLC |
Determination of Amygdalin in Maxing Oral Solution by HPLC |
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| LI Xiang,LIU Gui-yang,MA Jian-li,ZHOU Liang.Determination of Amygdalin in Maxing Oral Solution by HPLC[J].Pharmaceutical Journal of Chinese People's Liberation Army,2013(1):57-59. |
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| Authors: | LI Xiang LIU Gui-yang MA Jian-li ZHOU Liang |
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| Affiliation: | Department of Pharmacy,First Affiliated Hospital of PLA General Hospital,Beijing 100048,China |
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| Abstract: | Objective To establish an I-IPLC method for determination of amygdalin in Maxing oral solu- tion. Methods The Agilent Eclipse XDB-C18 （4.6 mm × 150 ram,5 μm） was used. The mobile phase consisted of methanol-water（20： 80） at a the flow rate of 1.0 ml .min-l. The detection wavelength was at 210 nm, the column was at room temperature, and the volume of injection was 10 μl. Results A good linear correlation of amygdalin was observed within the range of 4. 344-217.2 μg ·ml-1 （ r =0. 9999）. The average recovery was 102.08% with RSD of 1.75 % （ n = 6）. Conclusion This method is simple, accurate and quick, which can be used for determination and quality control of Maxing oral solution with good selectivity and repeatability. |
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| Keywords: | Maxing oral solution amygdalin HPLC |
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