Human granulocytic anaplasmosis in eastern France: clinical presentation and laboratory diagnosis |
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Authors: | Koebel Christelle Kern Aurélie Edouard Sophie Hoang Anh Thu Celestin Noéline Hansmann Yves Jaulhac Benoît Brouqui Philippe De Martino Sylvie Josiane |
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Affiliation: | 1. Laboratoire de Bactériologie, Hôpitaux Universitaires de Strasbourg, 1, rue Koeberlé, Strasbourg Cedex, France;2. Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), CNRS-IRD UMR 6236, Faculté de Médecine, Marseille, France;3. Service de Maladies Infectieuses et Tropicales, Hôpitaux Universitaires de Strasbourg, 1, place de l''hôpital BP 426, 67091 Strasbourg Cedex, France |
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Abstract: | Human granulocytic anaplasmosis (HGA) is a tick-borne infection characterised by an acute, nonspecific febrile illness. To date, few clinical cases have been supported by both a positive polymerase chain reaction (PCR) assay and subsequent seroconversion against Anaplasma phagocytophilum antigen all over Europe. We report here 3 consecutive cases of HGA that occurred during the summer of 2009 which fulfilled the epidemiologic, clinical, and biological criteria for HGA. These data highlight PCR assay on ethylenediaminetetraacetic acid blood rather than serology as the diagnostic test of choice during the acute phase of the disease. In endemic areas, HGA should be investigated in patients presenting an undifferentiated febrile illness with cytopenia, elevated rates of liver enzymes, and increased C-reactive protein values. |
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Keywords: | Human granulocytic anaplasmosis Anaplasma phagocytophilum PCR Serology France Ixodes ricinus |
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