| 两性霉素B/聚乙二醇-聚谷氨酸苄酯纳米球溶血毒性的研究 |
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| 引用本文： | 冯敏,潘仕荣,吴伟荣.两性霉素B/聚乙二醇-聚谷氨酸苄酯纳米球溶血毒性的研究[J].中国药科大学学报,2004,35(3):69-72. |
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| 作者姓名： | 冯敏 潘仕荣 吴伟荣 |
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| 作者单位： | 中山大学附属第一医院人工心脏研究室,广州,510080 |
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| 摘 要： | 目的:考察两性霉素B/聚乙二醇-聚谷氨酸(AmB/PEG-PBLG)纳米球是否能降低AmB的溶血毒性.方法:超微透析法制备AmB/PEG-PBLG纳米药球,用紫外分光光度法测定样品的溶血率.结果:AmB/PEG-PBLG纳米药球平均粒径142.1 nm,载药量27.55%;溶血率从低到高依次为:PEG-PBLG空白纳米球、脱氧胆酸钠、AmB/PEG-PBLG纳米药球、AmB注射液.结论:AmB/PEG-PBLG纳米药球能有效降低AmB的溶血毒性.
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| 关 键 词： | 两性霉素B 聚乙二醇 聚谷氨酸苄酯 纳米药球 溶血毒性 |
| 文章编号： | 1000-5048(2004)03-0263-04 |
| 修稿时间： | 2003年9月23日 |
Haemolytic Evaluation of Amphotericin B Loaded PEG-PBLG Nanospheres |
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| FENG Min,PAN Shi-Rong,WU Wei-Rong.Haemolytic Evaluation of Amphotericin B Loaded PEG-PBLG Nanospheres[J].Journal of China Pharmaceutical University,2004,35(3):69-72. |
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| Authors: | FENG Min PAN Shi-Rong WU Wei-Rong |
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| Abstract: | AIM:To investigate whether the amphotericin B (AmB) loaded PEG-PBLG nanospheres decreased the hemolytic toxicity.METHOD:AmB loaded PEG-PBLG nanospheres were prepared by diafiltration method.The haemolytic percentage was measured by UV.RESULT:The mean particle size was 142.1 nm and loading drug content was 27.55%.The haemolytic percentage from low to high were PEG-PBLG nanospheres,sodium deoxycholate,AmB loaded PEG-PBLG nanospheres,AmB injection.CONCLUSION:PEG-PBLG nanospheres are promising carriers to decrease the haemolytic toxicity of AmB. |
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| Keywords: | AmB PEG PBLG Nanospheres Hemolytic toxicity |
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