早期异位妊娠患者经阴道彩色多普勒示可疑妊娠滋养细胞流动与血清甲胎蛋白水平的相关性

摘要 目的：探究早期异位妊娠患者经阴道彩色多普勒示可疑妊娠滋养细胞流动与血清甲胎蛋白水平的相关性。方法：选择2021年1月至12月在本院收治的100例早期异位妊娠患者为观察研究对象。并选择同时期在本院例行正常产检的100例宫内妊娠孕妇为对照组。所有受试者进行阴道超声检查和彩色多普勒检查，并抽血进行甲胎蛋白的定量测定。测定子宫动脉、滋养细胞血流阻力及血清甲胎蛋白含量。结果：观察组腹痛、阴道不规则出血发生率较对照组升高（P<0.05）。观察组收缩期峰值速速、舒张末期速度较对照组升高，观察组滋养细胞血流阻力指数RI较对照组降低（P<0.05）。观察组收缩期峰值速速、舒张末期速度较对照组升高，观察组子宫动脉血流阻力指数RI较对照组降低（P<0.05）。观察组血清甲胎蛋白含量较对照组升高（P<0.05）。异位妊娠患者血清甲胎蛋白与滋养细胞血流RI呈负相关（r=-0.425，P<0.001）。结论：早期异位妊娠患者血清甲胎蛋白升高，经阴道彩色多普勒检查显示滋养细胞存在高流量-低阻力血管，滋养细胞血流阻力RI与血清甲胎蛋白呈负相关。

Correlation between Suspected Gestational Trophoblastic Flow and Serum Alpha-fetoprotein Level in Patients with Early Ectopic Pregnancy by Transvaginal Color Doppler

ABSTRACT Objective: To explore the correlation between suspected gestational trophoblastic flow and serum alpha-fetoprotein level in patients with early ectopic pregnancy. Methods: 100 patients with early ectopic pregnancy who were admitted to our hospital from January to December 2021 were selected as observational research objects. And 100 pregnant women with intrauterine pregnancy who received routine normal obstetric examination in our hospital during the same period were selected as the matched group. All subjects underwent transvaginal ultrasonography and color Doppler examination, and blood was drawn for quantitative determination of alpha-fetoprotein. Uterine artery, trophoblast blood flow resistance and serum alpha-fetoprotein content were measured. Results: The incidence of abdominal pain and irregular vaginal bleeding in the observation group was higher than that in the matched group (P<0.05). The peak systolic velocity and end-diastolic velocity of the observation group were higher than those of the matched group, and the trophoblastic blood flow resistance index RI of the observation group was lower than that of the matched group (P<0.05). The peak systolic velocity and end-diastolic velocity in the observation group were higher than those in the matched group, and the uterine artery blood flow resistance index RI in the observation group was lower than that in the matched group(P<0.05). The serum alpha-fetoprotein content in the observation group was higher than that in the matched group (P<0.05). Serum alpha-fetoprotein was negatively correlated with trophoblastic blood flow RI in patients with ectopic pregnancy (r=-0.425, P<0.001). Conclusion: Serum alpha-fetoprotein is elevated in patients with early ectopic pregnancy. Transvaginal color Doppler examination shows that there are high-flow-low-resistance blood vessels in trophoblast cells. The blood flow resistance of trophoblast cells is negatively correlated with serum alpha-fetoprotein.