| Smith抗原的性质特征及临床意义 |
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| 引用本文： | 吴文冰,兰小鹏.Smith抗原的性质特征及临床意义[J].医学研究生学报,2007,20(1):90-93. |
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| 作者姓名： | 吴文冰 兰小鹏 |
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| 作者单位： | 南京军区福州总医院解放军医学检验中心,福建福州,350025 |
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| 基金项目： | 福建省青年科技人才创新基金 |
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| 摘 要： | 系统性红斑狼疮（SLE）是一种自身免疫性疾病，患者血清中可检出多种自身抗体，但抗Smith（Sm）抗体是SLE的标记性抗体。作者就Sm抗原的理化特性、生物学作用和抗Sm抗体的检测作一综述。
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| 关 键 词： | 系统性红斑狼疮 Smith抗原 理化特性 生物学作用 |
| 文章编号： | 1008-8199(2007)01-0090-04 |
| 修稿时间： | 2006年3月16日 |
Characterization and clinical significance of the Smith antigen |
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| WU Wen-bing,LAN Xiao-peng.Characterization and clinical significance of the Smith antigen[J].Bulletin of Medical Postgraduate,2007,20(1):90-93. |
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| Authors: | WU Wen-bing LAN Xiao-peng |
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| Abstract: | Systemic lupus erythematosus(SLE) is an autoimmune disease characterized by the production of autoantibodies against a wide spectrum of nuclear, cytoplasmic,and cell membrane autoantigens.Among them,the anti-Smith antibodies are specific for SLE and thus have been included as a criteria for diagnosis.They are not only a diagnostic marker but also a reliable measure of disease activity in SLE,we intend to describe the biological functions and clinical significance of the Smith antigen and the detection of anti-Smith antibodies. |
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| Keywords: | Systemic lupus erythematosus The Smith antigen Characterization Biological functions |
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